DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: DEG_SCF_FBW7_1

Location: 1199:1205

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 71.7143

COIL: 0.9537

CONS_SCORE: 0.4003

DSS_SCORE: 0.8404

HELIX: 0.0174

FCONS_SCORE: 1.0547

RIG_SCORE: 0.5542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1203I	TCGA-13-0903	OV	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.7618
p.M1203I	DO32616	OV	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.7618
p.G1208C	TCGA-43-2581	LUSC	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.25
p.G1208C	DO26602	LUSC	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.25
p.G1199A	TCGA-55-8089	LUAD	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.754
p.G1199A	DO23690	LUAD	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.754
p.P1195L	TCGA-D3-A8GM	SKCM	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.2222
p.P1195L	DO50288	SKCM	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.2222
p.S1202F	DO232224	PBCA	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.7982
p.A1200D	AGS	stomach	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.7793
p.N1198S	NCI-H2347	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.3056
p.A1193D	AGS	stomach	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.1667
p.E1212K	SNU-1040	large_intestine	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.1389
p.M1213V	42-MG-BA	central_nervous_system	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.1111
p.N1191S	NCI-H2347	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_FBW7_1	1162:1168	PPTPAST	FBXW7	0.9973	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SCF_FBW7_1	1199:1205	PPTPAST	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons