DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SCF_FBW7_1

Location: 1162:1168

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 83.0857

COIL: 0.9677

CONS_SCORE: 0.5028

DSS_SCORE: 0.8536

HELIX: 0.0131

FCONS_SCORE: 1.1618

RIG_SCORE: 0.5394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1165Q	TCGA-D3-A3C6	SKCM	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.7035
p.P1165Q	DO37507	SKCM	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.7035
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PPTPAST	DEG_SCF_FBW7_1	0.1111
p.M1154T	DO41704	UCEC	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.1111
p.M1154I	DO227987	COCA	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.1111
p.E1156G	DO23490	LINC	ICGC	PPTPAST	DEG_SCF_FBW7_1	0.1667
p.I1173N	SIDM02059	Colorectal Carcinoma	GDSC	PPTPAST	DEG_SCF_FBW7_1	0.1944
p.G1178A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTPAST	DEG_SCF_FBW7_1	0.0556
p.G1178A	ACH-000929	Lung Cancer	CCLE	PPTPAST	DEG_SCF_FBW7_1	0.0556
p.G1178A	NCI-H2110	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_FBW7_1	1162:1168	PPTPAST	FBXW7	0.9973	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SCF_FBW7_1	1199:1205	PPTPAST	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons