DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: DEG_SCF_FBW7_1

Location: 1179:1185

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 96.0857

COIL: 0.9563

CONS_SCORE: 0.4212

DSS_SCORE: 0.8507

HELIX: 0.02

FCONS_SCORE: 1.1165

RIG_SCORE: 0.5175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1183H	TCGA-55-6981	LUAD	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.7694
p.P1183H	DO24265	LUAD	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.7694
p.P1176S	TCGA-A5-A0G2	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.25
p.P1176S	DO41235	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.25
p.A1184S	TCGA-A8-A09W	BRCA	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.7588
p.A1184S	DO1476	BRCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.7588
p.P1195L	TCGA-D3-A8GM	SKCM	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.0556
p.P1195L	DO50288	SKCM	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.0556
p.P1183T	TCGA-IB-7651	PAAD	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.7031
p.P1183T	DO46657	PAAD	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.7031
p.K1177R	DO222700	BTCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.2778
p.G1187V	DO228985	LICA	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.2778
p.G1187V	DO229028	LICA	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.2778
p.Y1188C	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PQTPQST	DEG_SCF_FBW7_1	0.25
p.Y1188C	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.25
p.G1187E	ACH-001335	Cervical Cancer	CCLE	PQTPQST	DEG_SCF_FBW7_1	0.2778
p.A1193D	AGS	stomach	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.1111
p.D1176A	NCI-H1876	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.25
p.N1191S	NCI-H2347	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.1667
p.D1169A	NCI-H1876	lung	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_FBW7_1	1144:1150	PQTPQST	FBXW7	0.9027	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SCF_FBW7_1	1179:1185	PQTPQST	FBXW7	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons