DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SCF_FBW7_1

Location: 1144:1150

E3 ligase: FBXW7

DEGRON score: 0.9027

ASA_SCORE: 84.6429

COIL: 0.9519

CONS_SCORE: 0.4315

DSS_SCORE: 0.8611

HELIX: 0.0221

FCONS_SCORE: 0.9461

RIG_SCORE: 0.5084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1144S	TCGA-B5-A11E	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.6752
p.P1144S	DO41644	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.6752
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	0.2222
p.M1154T	DO41704	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.2222
p.M1154I	DO227987	COCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.2222
p.E1156G	DO23490	LINC	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.1667
p.G1139V	DO45819	NBL	ICGC	PQTPQST	DEG_SCF_FBW7_1	0.1944
p.P1144T	SIDM00131	Glioma	GDSC	PQTPQST	DEG_SCF_FBW7_1	0.7031
p.P1144T	ACH-000329	Brain Cancer	CCLE	PQTPQST	DEG_SCF_FBW7_1	0.7031
p.P1144T	CCF-STTG1	central_nervous_system	COSMIC	PQTPQST	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_FBW7_1	1144:1150	PQTPQST	FBXW7	0.9027	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SCF_FBW7_1	1179:1185	PQTPQST	FBXW7	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons