DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: CBL_PTK

Location: 978:988

E3 ligase: CBL

DEGRON score: 0.8251

ASA_SCORE: 93.5364

COIL: 0.9448

CONS_SCORE: 0.4215

DSS_SCORE: 0.4448

HELIX: 0.0401

FCONS_SCORE: 1.2252

RIG_SCORE: 0.6713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q969H	TCGA-50-6590	LUAD	TCGA	NTQAPPYSMAP	CBL_PTK	0.0833
p.Q969H	DO24692	LUAD	ICGC	NTQAPPYSMAP	CBL_PTK	0.0833
p.N984K	TCGA-AO-A0J2	BRCA	TCGA	NTQAPPYSMAP	CBL_PTK	0.6918
p.N984K	DO2252	BRCA	ICGC	NTQAPPYSMAP	CBL_PTK	0.6918
p.N984K	DO229045	LICA	ICGC	NTQAPPYSMAP	CBL_PTK	0.6918
p.T992M	TCGA-AX-A1CE	UCEC	TCGA	NTQAPPYSMAP	CBL_PTK	0.2222
p.T992M	DO42280	UCEC	ICGC	NTQAPPYSMAP	CBL_PTK	0.2222
p.Y997H	TCGA-QK-A652	HNSC	TCGA	NTQAPPYSMAP	CBL_PTK	0.0833
p.Y997H	DO49999	HNSC	ICGC	NTQAPPYSMAP	CBL_PTK	0.0833
p.Y997H	DO229257	THCA	ICGC	NTQAPPYSMAP	CBL_PTK	0.0833
p.A987V	SIDM02072	Colorectal Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.5825
p.V991L	SIDM00212	Glioblastoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.25
p.V991L	CAS-1	central_nervous_system	COSMIC	NTQAPPYSMAP	CBL_PTK	0.25
p.A996S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.1111
p.A996S	NCI-H322M	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	0.1111
p.P982S	SIDM01128	Small Cell Lung Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.5641
p.P982S	NCI-H526	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	0.5641
p.A981V	SIDM01608	Endometrial Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.5825
p.P988S	SIDM01608	Endometrial Carcinoma	GDSC	NTQAPPYSMAP	CBL_PTK	0.6752
p.P995S	ACH-000767	Lung Cancer	CCLE	NTQAPPYSMAP	CBL_PTK	0.1389
p.P995S	NCI-H526	lung	COSMIC	NTQAPPYSMAP	CBL_PTK	0.1389
p.A994V	ACH-000990	Endometrial/Uterine Cancer	CCLE	NTQAPPYSMAP	CBL_PTK	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFD5	AT-rich interactive domain-containing protein 1B	CBL_PTK	978:988	NTQAPPYSMAP	CBL	0.8251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons