DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: DEG_SCF_FBW7_1

Location: 503:509

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 75.3857

COIL: 0.9681

CONS_SCORE: 0.2626

DSS_SCORE: 0.8204

HELIX: 0.0149

FCONS_SCORE: 1.2325

RIG_SCORE: 0.4917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q494P	DO1020	BRCA	ICGC	PGTPGPT	DEG_SCF_FBW7_1	0.0833
p.G515A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTPGPT	DEG_SCF_FBW7_1	0.1667
p.G515A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	0.1667
p.S497N	SIDM00935	Other Solid Cancers	GDSC	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.S497N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.S497N	ACH-002091	Skin Cancer	CCLE	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.S497N	ACH-002222	Leukemia	CCLE	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.S497N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.S497N	CAL-39	vulva	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	0.6111
p.P508S	SIDM00856	Other Solid Cancers	GDSC	PGTPGPT	DEG_SCF_FBW7_1	0.5641
p.P506L	SIDM00516	Melanoma	GDSC	PGTPGPT	DEG_SCF_FBW7_1	0.7582
p.P506L	ACH-002166	Skin Cancer	CCLE	PGTPGPT	DEG_SCF_FBW7_1	0.7582
p.P506L	MZ7-mel	skin	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	0.7582
p.M516V	42-MG-BA	central_nervous_system	COSMIC	PGTPGPT	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SCF_FBW7_1	503:509	PGTPGPT	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons