DegronMD

Uniprot ID: Q8NFD5

Source protein: AT-rich interactive domain-containing protein 1B

Source gene: ARID1B

Class: DEG_SPOP_SBC_1

Location: 1118:1122

E3 ligase: SPOP

DEGRON score: 0.5867

ASA_SCORE: 63.18

COIL: 0.8884

CONS_SCORE: 0.5163

DSS_SCORE: 0.2227

HELIX: 0.0604

FCONS_SCORE: 0.8908

RIG_SCORE: 0.7284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1112C	TCGA-D3-A2J6	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1667
p.G1112C	DO37901	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.N1119S	TCGA-DU-6392	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	0.7069
p.N1119S	DO22237	LGG	ICGC	VGTSS	DEG_SPOP_SBC_1	0.7069
p.E1124K	TCGA-ZF-AA51	BLCA	TCGA	VGTSS	DEG_SPOP_SBC_1	0.2778
p.E1124K	DO219093	BLCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2778
p.L1129R	DO234188	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.G1111R	DO23338	LINC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1389
p.G1111R	ACH-000449	Sarcoma	CCLE	VGTSS	DEG_SPOP_SBC_1	0.1389
p.G1111R	MES-SA	soft_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.1389
p.G1112D	DO32887	PACA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.L1129P	DO229459	SKCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.A1132V	SIDM01088	Endometrial Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.A1132V	RL95-2	endometrium	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.D1114N	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.6667
p.D1114N	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.6667
p.L1130R	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.L1130R	NCI-H3122	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.D1108N	NCI-H630	large_intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.D1115N	NCI-H630	large_intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons