DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VGTSS
Uniprot ID:
O75461
Source protein:
Transcription factor E2F6
Source gene:
E2F6
Class:
DEG_SPOP_SBC_1
Location:
251:255
E3 ligase:
SPOP
DEGRON score:
0.9975
ASA_SCORE:
68.32
COIL:
0.937
CONS_SCORE:
0.4365
DSS_SCORE:
0.8083
HELIX:
0.0376
FCONS_SCORE:
1.165
RIG_SCORE:
0.4998
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V251D
ACH-001513
Cervical Cancer
CCLE
VGTSS
DEG_SPOP_SBC_1
0.7785
p.T253I
SIDM01237
Hepatocellular Carcinoma
GDSC
VGTSS
DEG_SPOP_SBC_1
0.7078
p.G252W
TCGA-A8-A09Z
BRCA
TCGA
VGTSS
DEG_SPOP_SBC_1
0.6714
p.R247K
SIDM00043
Head and Neck Carcinoma
GDSC
VGTSS
DEG_SPOP_SBC_1
0.2222
p.R247K
SIDM00115
Head and Neck Carcinoma
GDSC
VGTSS
DEG_SPOP_SBC_1
0.2222
p.R247K
ACH-002298
Head and Neck Cancer
CCLE
VGTSS
DEG_SPOP_SBC_1
0.2222
p.R247K
PCI-4B
upper_aerodigestive_tract
COSMIC
VGTSS
DEG_SPOP_SBC_1
0.2222
p.R247K
PCI-6A
upper_aerodigestive_tract
COSMIC
VGTSS
DEG_SPOP_SBC_1
0.2222
p.P261L
TCGA-32-1977
GBM
TCGA
VGTSS
DEG_SPOP_SBC_1
0.1667
p.P264S
TCGA-YD-A9TA
SKCM
TCGA
VGTSS
DEG_SPOP_SBC_1
0.0833
p.E265D
SIDM00477
Esophageal Carcinoma
GDSC
VGTSS
DEG_SPOP_SBC_1
0.0556
p.E265D
ACH-000383
Esophageal Cancer
CCLE
VGTSS
DEG_SPOP_SBC_1
0.0556
p.E265D
OE33
oesophagus
COSMIC
VGTSS
DEG_SPOP_SBC_1
0.0556
Showing 1 to 13 of 13 entries
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Drug responses associated with E2F6 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VGTSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14497
AT-rich interactive domain-containing protein 1A
DEG_SPOP_SBC_1
1082:1086
VGTSS
SPOP
0.8602
More...
Q8NFD5
AT-rich interactive domain-containing protein 1B
DEG_SPOP_SBC_1
1118:1122
VGTSS
SPOP
0.5867
More...
Q8TE68
Epidermal growth factor receptor kinase substrate 8-like protein 1
DEG_SPOP_SBC_1
229:233
VGTSS
SPOP
0.9487
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7482:7486
VGTSS
SPOP
0.9982
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8061:8065
VGTSS
SPOP
0.9927
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
2159:2163
VGTSS
SPOP
0.9597
More...
P08397
Porphobilinogen deaminase
DEG_SPOP_SBC_1
143:147
VGTSS
SPOP
0.5283
More...
P43119
Prostacyclin receptor
DEG_SPOP_SBC_1
371:375
VGTSS
SPOP
0.9613
More...
A4D161
Protein FAM221A
DEG_SPOP_SBC_1
249:253
VGTSS
SPOP
0.845
More...
Q9NQX0
Putative histone-lysine N-methyltransferase PRDM6
DEG_SPOP_SBC_1
223:227
VGTSS
SPOP
0.9484
More...
P86434
Putative uncharacterized protein ADORA2A-AS1
DEG_SPOP_SBC_1
48:52
VGTSS
SPOP
0.7315
More...
Q9C0B0
RING finger protein unkempt homolog
DEG_SPOP_SBC_1
489:493
VGTSS
SPOP
0.9747
More...
O75461
Transcription factor E2F6
DEG_SPOP_SBC_1
251:255
VGTSS
SPOP
0.9975
More...
Showing 1 to 13 of 13 entries
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