DegronMD

Uniprot ID: O75461

Source protein: Transcription factor E2F6

Source gene: E2F6

Class: DEG_SPOP_SBC_1

Location: 251:255

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 68.32

COIL: 0.937

CONS_SCORE: 0.4365

DSS_SCORE: 0.8083

HELIX: 0.0376

FCONS_SCORE: 1.165

RIG_SCORE: 0.4998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P261L	TCGA-32-1977	GBM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1667
p.G252W	TCGA-A8-A09Z	BRCA	TCGA	VGTSS	DEG_SPOP_SBC_1	0.6714
p.P264S	TCGA-YD-A9TA	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0833
p.T253I	SIDM01237	Hepatocellular Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.7078
p.E265D	SIDM00477	Esophageal Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.E265D	ACH-000383	Esophageal Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.0556
p.E265D	OE33	oesophagus	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.R247K	SIDM00043	Head and Neck Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.R247K	SIDM00115	Head and Neck Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.R247K	ACH-002298	Head and Neck Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.2222
p.R247K	PCI-4B	upper_aerodigestive_tract	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.R247K	PCI-6A	upper_aerodigestive_tract	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.V251D	ACH-001513	Cervical Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons