DegronMD - Q8TE68(EPS8L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P228A	TCGA-66-2780	LUSC	TCGA	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.G114S	TCGA-E2-A159	BRCA	TCGA	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.2778
p.P120H	DO218488	BRCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.7694
p.T123S	DO225232	BRCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.7116
p.R224W	DO222414	BTCA	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.L130V	DO229383	BTCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1667
p.R129H	DO7849	COAD	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1944
p.R226C	DO8490	COAD	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.R226C	DO8224	COAD	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.R226C	DO222342	STAD	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.R226C	HEC-1	endometrium	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.G123S	DO50329	ESAD	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.6993
p.R231Q	DO234208	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7329
p.V242L	DO234393	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.0833
p.R122H	DO233693	GACA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.8244
p.R122H	DO233764	GACA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.8244
p.R122H	DO43714	UCEC	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.8244
p.G227S	DO52107	HNSC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.P240A	DO219201	LUSC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.S238R	DO50707	ORCA	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.R120L	DO229502	SKCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.8428
p.S118A	DO229245	THCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.7588
p.G234A	DO48173	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.P236A	DO40924	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.P236A	DO41337	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.P236A	DO230449	UTCA	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.R228S	DO42033	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.R129C	DO42384	UCEC	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1944
p.R106H	SIDM01039	Other Solid Cancers	GDSC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.0556
p.E227D	ACH-000744	Lung Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.S118W	ACH-001414	Bladder Cancer	CCLE	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.7874
p.A130V	ACH-001838	Bile Duct Cancer	CCLE	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1667
p.R225Q	PL-21	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2222
p.S230R	NCI-H1563	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7427
p.I133N	ME-1	haematopoietic and lymphoid tissue	COSMIC	SRSLLLLVC	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.0833
p.I242N	ME-1	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.0833
p.S233L	HCC-78	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.7667
p.R234H	SLVL	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056

Kaplan plot for EPS8L1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPS8L1

UniProt ID: Q8TE68

Entrez ID: 54869

Protein name: Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPS8L1 in