DegronMD

Uniprot ID: Q8TE68

Source protein: Epidermal growth factor receptor kinase substrate 8-like protein 1

Source gene: EPS8L1

Class: DEG_APCC_DBOX_1

Location: 116:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7598

ASA_SCORE: 20.3111

COIL: 0.2384

CONS_SCORE: 0.4511

DSS_SCORE: 0.2584

HELIX: 0.024

FCONS_SCORE: 1.297

RIG_SCORE: 0.8322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G114S	TCGA-E2-A159	BRCA	TCGA	SRSLLLLVC	DEG_APCC_DBOX_1	0.2778
p.P120H	DO218488	BRCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.7694
p.T123S	DO225232	BRCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.7116
p.L130V	DO229383	BTCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.1667
p.R129H	DO7849	COAD	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.1944
p.G123S	DO50329	ESAD	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.6993
p.R122H	DO233693	GACA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.8244
p.R122H	DO233764	GACA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.8244
p.R122H	DO43714	UCEC	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.8244
p.R120L	DO229502	SKCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.8428
p.S118A	DO229245	THCA	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.7588
p.R129C	DO42384	UCEC	ICGC	SRSLLLLVC	DEG_APCC_DBOX_1	0.1944
p.R106H	SIDM01039	Other Solid Cancers	GDSC	SRSLLLLVC	DEG_APCC_DBOX_1	0.0556
p.S118W	ACH-001414	Bladder Cancer	CCLE	SRSLLLLVC	DEG_APCC_DBOX_1	0.7874
p.A130V	ACH-001838	Bile Duct Cancer	CCLE	SRSLLLLVC	DEG_APCC_DBOX_1	0.1667
p.I133N	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRSLLLLVC	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_APCC_DBOX_1	116:124	SRSLLLLVC	APC,CDC20,FZR1	0.7598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons