DegronMD

Uniprot ID: Q8TE68

Source protein: Epidermal growth factor receptor kinase substrate 8-like protein 1

Source gene: EPS8L1

Class: DEG_SPOP_SBC_1

Location: 229:233

E3 ligase: SPOP

DEGRON score: 0.9487

ASA_SCORE: 70.14

COIL: 0.906

CONS_SCORE: 0.2659

DSS_SCORE: 0.803

HELIX: 0.0424

FCONS_SCORE: 0.8066

RIG_SCORE: 0.5375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P228A	TCGA-66-2780	LUSC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.3056
p.R224W	DO222414	BTCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.R226C	DO8490	COAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R226C	DO8224	COAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R226C	DO222342	STAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R226C	HEC-1	endometrium	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R231Q	DO234208	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.7329
p.V242L	DO234393	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.G227S	DO52107	HNSC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2778
p.P240A	DO219201	LUSC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1389
p.S238R	DO50707	ORCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.G234A	DO48173	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.3056
p.P236A	DO40924	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.P236A	DO41337	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.P236A	DO230449	UTCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R228S	DO42033	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.3056
p.E227D	ACH-000744	Lung Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.2778
p.R225Q	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.S230R	NCI-H1563	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.7427
p.I242N	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.S233L	HCC-78	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.7667
p.R234H	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons