DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 7482:7486

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 75.64

COIL: 0.8342

CONS_SCORE: 0

DSS_SCORE: 0.5747

HELIX: 0.0152

FCONS_SCORE: 0

RIG_SCORE: 0.6039

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S7493Y	TCGA-44-3918	LUAD	TCGA	VGTSS	DEG_SPOP_SBC_1	0.5833
p.S7493Y	DO23732	LUAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.5833
p.S7485Y	TCGA-78-7539	LUAD	TCGA	VGTSS	DEG_SPOP_SBC_1	0.712
p.S7485Y	DO26210	LUAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.712
p.A7478T	TCGA-DF-A2KU	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.2222
p.A7478T	DO223286	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.P7473S	TCGA-EE-A17X	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0833
p.P7473S	TCGA-EE-A2MR	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0833
p.P7473S	TCGA-IR-A3LA	CESC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0833
p.P7473S	DO44377	CESC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.P7473S	DO37819	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.P7473S	DO37931	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.H7472Y	TCGA-EE-A3JD	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0556
p.H7472Y	DO50299	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.S7485F	TCGA-FR-A8YC	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.7982
p.S7485F	DO50301	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.7982
p.S7491F	TCGA-YD-A9TA	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1944
p.S7491F	DO219503	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.P7492H	DO229029	LICA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.P7492S	DO220913	MELA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.P7492S	DO229456	SKCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.T7477M	SIDM00773	Non-Cancerous	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM00967	Ovarian Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM01133	Other Solid Cancers	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM00774	Breast Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM00720	Mesothelioma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.T7477M	SIDM01409	Bladder Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.S7486G	SIDM01413	Oral Cavity Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.6993
p.S7486G	ACH-000630	Head and Neck Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.6993
p.S7486G	ACH-001540	Liposarcoma	CCLE	VGTSS	DEG_SPOP_SBC_1	0.6993
p.S7486G	ACH-002785	Unknown	CCLE	VGTSS	DEG_SPOP_SBC_1	0.6993
p.P7473H	ACH-001977	Primary	CCLE	VGTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VGTSS