DegronMD - O75461(E2F6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P261L	TCGA-32-1977	GBM	TCGA	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1667
p.G252W	TCGA-A8-A09Z	BRCA	TCGA	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.6714
p.P264S	TCGA-YD-A9TA	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.T253I	SIDM01237	Hepatocellular Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7078
p.E265D	SIDM00477	Esophageal Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.E265D	ACH-000383	Esophageal Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.E265D	OE33	oesophagus	COSMIC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.R247K	SIDM00043	Head and Neck Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.R247K	SIDM00115	Head and Neck Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.R247K	ACH-002298	Head and Neck Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.R247K	PCI-4B	upper aerodigestive tract	COSMIC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.R247K	PCI-6A	upper aerodigestive tract	COSMIC	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.V251D	ACH-001513	Cervical Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7785

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons