DegronMD - Q9C0B0(UNK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P486H	TCGA-46-3765	LUSC	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.25
p.S472G	TCGA-AP-A051	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	468:472	Mutation altering degron motif	0.6993
p.G490D	TCGA-D1-A17H	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.6087
p.P485H	TCGA-D3-A3CC	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2222
p.A501T	TCGA-DF-A2KN	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1111
p.A501T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1111
p.A499V	TCGA-EO-A22U	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.G496D	TCGA-TQ-A7RO	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.25
p.E503K	DO219730	CESC	ICGC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.0556
p.E495K	DO52107	HNSC	ICGC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.G460C	DO47578	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	468:472	Mutation rewiring degron network	0.1111
p.P492L	DO51259	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7582
p.V494I	SIDM00789	Colorectal Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.V494I	HCT-15	large intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.S493R	SIDM00877	Breast Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7427
p.S493R	ACH-000196	Breast Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7427
p.S493R	HCC1599	breast	COSMIC	VGTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7427

Kaplan plot for UNK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNK

UniProt ID: Q9C0B0

Entrez ID: 85451

Protein name: RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNK in