DegronMD

Uniprot ID: Q9C0B0

Source protein: RING finger protein unkempt homolog

Source gene: UNK

Class: DEG_SPOP_SBC_1

Location: 489:493

E3 ligase: SPOP

DEGRON score: 0.9747

ASA_SCORE: 69.5

COIL: 0.9162

CONS_SCORE: 0.4055

DSS_SCORE: 0.4882

HELIX: 0.0228

FCONS_SCORE: 0.8804

RIG_SCORE: 0.6243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P486H	TCGA-46-3765	LUSC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.25
p.G490D	TCGA-D1-A17H	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.6087
p.P485H	TCGA-D3-A3CC	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.2222
p.A501T	TCGA-DF-A2KN	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1111
p.A501T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.1111
p.A499V	TCGA-EO-A22U	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1667
p.G496D	TCGA-TQ-A7RO	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	0.25
p.E503K	DO219730	CESC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.0556
p.E495K	DO52107	HNSC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2778
p.P492L	DO51259	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.7582
p.V494I	SIDM00789	Colorectal Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.3056
p.V494I	HCT-15	large_intestine	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.3056
p.S493R	SIDM00877	Breast Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.7427
p.S493R	ACH-000196	Breast Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.7427
p.S493R	HCC1599	breast	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons