DegronMD

Uniprot ID: A4D161

Source protein: Protein FAM221A

Source gene: FAM221A

Class: DEG_SPOP_SBC_1

Location: 249:253

E3 ligase: SPOP

DEGRON score: 0.845

ASA_SCORE: 65.84

COIL: 0.7252

CONS_SCORE: 0.2843

DSS_SCORE: 0.5923

HELIX: 0.2508

FCONS_SCORE: 0.9082

RIG_SCORE: 0.6436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E263A	TCGA-D3-A3C8	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.0556
p.T245P	TCGA-DX-A3UA	SARC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.2222
p.T245M	SIDM00321	Ovarian Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.T245M	ACH-000430	Ovarian Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.2222
p.T245M	TYK-nu	ovary	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.P261T	SIDM00001	Other Blood Cancers	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1111
p.S256F	SIDM00938	Breast Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.25
p.S256F	ACH-000902	Breast Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.25
p.S256F	CAL-148	breast	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.25
p.K250E	NCI-H64	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons