DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VGTSS
Uniprot ID:
P86434
Source protein:
Putative uncharacterized protein ADORA2A-AS1
Source gene:
ADORA2A-AS1
Class:
DEG_SPOP_SBC_1
Location:
48:52
E3 ligase:
SPOP
DEGRON score:
0.7315
ASA_SCORE:
50.78
COIL:
0.6636
CONS_SCORE:
0
DSS_SCORE:
0.4208
HELIX:
0.094
FCONS_SCORE:
0
RIG_SCORE:
0.7081
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ADORA2A-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A4D161
Protein FAM221A
DEG_SPOP_SBC_1
249:253
VGTSS
SPOP
0.845
More...
O14497
AT-rich interactive domain-containing protein 1A
DEG_SPOP_SBC_1
1082:1086
VGTSS
SPOP
0.8602
More...
O75461
Transcription factor E2F6
DEG_SPOP_SBC_1
251:255
VGTSS
SPOP
0.9975
More...
P08397
Porphobilinogen deaminase
DEG_SPOP_SBC_1
143:147
VGTSS
SPOP
0.5283
More...
P43119
Prostacyclin receptor
DEG_SPOP_SBC_1
371:375
VGTSS
SPOP
0.9613
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
2159:2163
VGTSS
SPOP
0.9597
More...
Q8NFD5
AT-rich interactive domain-containing protein 1B
DEG_SPOP_SBC_1
1118:1122
VGTSS
SPOP
0.5867
More...
Q8TE68
Epidermal growth factor receptor kinase substrate 8-like protein 1
DEG_SPOP_SBC_1
229:233
VGTSS
SPOP
0.9487
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
7482:7486
VGTSS
SPOP
0.9982
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8061:8065
VGTSS
SPOP
0.9927
More...
Q9C0B0
RING finger protein unkempt homolog
DEG_SPOP_SBC_1
489:493
VGTSS
SPOP
0.9747
More...
Q9NQX0
Putative histone-lysine N-methyltransferase PRDM6
DEG_SPOP_SBC_1
223:227
VGTSS
SPOP
0.9484
More...
P86434
Putative uncharacterized protein ADORA2A-AS1
DEG_SPOP_SBC_1
48:52
VGTSS
SPOP
0.7315
More...