DegronMD

Uniprot ID: Q9NQX0

Source protein: Putative histone-lysine N-methyltransferase PRDM6

Source gene: PRDM6

Class: DEG_SPOP_SBC_1

Location: 223:227

E3 ligase: SPOP

DEGRON score: 0.9484

ASA_SCORE: 68.92

COIL: 0.8114

CONS_SCORE: 0.5887

DSS_SCORE: 0.4847

HELIX: 0.1538

FCONS_SCORE: 1.0168

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R220H	TCGA-2H-A9GQ	ESCA	TCGA	VGTSS	DEG_SPOP_SBC_1	0.25
p.T225A	DO234376	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.7139
p.A228T	DO234457	ESAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.3056
p.P235T	DO229257	THCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1111
p.R220L	SIDM00427	Ewing's Sarcoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R220L	SIDM01162	Kidney Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R220L	ACH-001398	Kidney Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.25
p.P234S	SIDM01087	Melanoma	GDSC	VGTSS	DEG_SPOP_SBC_1	0.1389
p.P234L	ACH-002041	Thyroid Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons