DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SPOP_SBC_1

Location: 1082:1086

E3 ligase: SPOP

DEGRON score: 0.8602

ASA_SCORE: 69.52

COIL: 0.9176

CONS_SCORE: 0.678

DSS_SCORE: 0.2493

HELIX: 0.0492

FCONS_SCORE: 1.0406

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1083C	TCGA-97-7938	LUAD	TCGA	VGTSS	DEG_SPOP_SBC_1	0.6489
p.G1083C	DO24329	LUAD	ICGC	VGTSS	DEG_SPOP_SBC_1	0.6489
p.S1090I	TCGA-B5-A11E	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	0.2222
p.S1090I	DO41644	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2222
p.R1074L	TCGA-EE-A2GH	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	0.1111
p.R1074L	DO37643	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1111
p.A1089T	TCGA-TM-A84M	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	0.25
p.A1089T	DO50238	LGG	ICGC	VGTSS	DEG_SPOP_SBC_1	0.25
p.R1074W	DO225388	BRCA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1111
p.L1080I	DO228672	LICA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.2778
p.A1077T	DO228903	LICA	ICGC	VGTSS	DEG_SPOP_SBC_1	0.1944
p.P1072L	SK-MEL-28	skin	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.1667
p.R1079H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.25
p.P1073L	SK-MEL-28	skin	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.0833
p.R1080H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	249:253	VGTSS	SPOP	0.845	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1082:1086	VGTSS	SPOP	0.8602	More...
O75461	Transcription factor E2F6	DEG_SPOP_SBC_1	251:255	VGTSS	SPOP	0.9975	More...
P08397	Porphobilinogen deaminase	DEG_SPOP_SBC_1	143:147	VGTSS	SPOP	0.5283	More...
P43119	Prostacyclin receptor	DEG_SPOP_SBC_1	371:375	VGTSS	SPOP	0.9613	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2159:2163	VGTSS	SPOP	0.9597	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	DEG_SPOP_SBC_1	1118:1122	VGTSS	SPOP	0.5867	More...
Q8TE68	Epidermal growth factor receptor kinase substrate 8-like protein 1	DEG_SPOP_SBC_1	229:233	VGTSS	SPOP	0.9487	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7482:7486	VGTSS	SPOP	0.9982	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8061:8065	VGTSS	SPOP	0.9927	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	489:493	VGTSS	SPOP	0.9747	More...
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6	DEG_SPOP_SBC_1	223:227	VGTSS	SPOP	0.9484	More...
P86434	Putative uncharacterized protein ADORA2A-AS1	DEG_SPOP_SBC_1	48:52	VGTSS	SPOP	0.7315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons