DegronMD - A4D161(FAM221A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V217F	TCGA-77-8133	LUSC	TCGA	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation altering degron motif	0.5957
p.S241F	TCGA-95-7043	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7982
p.D228Y	TCGA-AC-A23H	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.F231L	TCGA-BP-4782	KIRC	TCGA	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.R206W	TCGA-BR-4184	STAD	TCGA	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.2778
p.E263A	TCGA-D3-A3C8	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.T245P	TCGA-DX-A3UA	SARC	TCGA	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.T245P	TCGA-DX-A3UA	SARC	TCGA	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.D208H	TCGA-IQ-7630	HNSC	TCGA	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation altering degron motif	0.7688
p.P230S	TCGA-WE-A8ZX	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.S221L	DO225037	BRCA	ICGC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.2222
p.E227A	DO47636	SKCM	ICGC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.0556
p.E227A	DO47636	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.T245M	SIDM00321	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.T245M	SIDM00321	Ovarian Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.T245M	ACH-000430	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.T245M	ACH-000430	Ovarian Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.T245M	TYK-nu	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.T245M	TYK-nu	ovary	COSMIC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.P261T	SIDM00001	Other Blood Cancers	GDSC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1111
p.S256F	SIDM00938	Breast Carcinoma	GDSC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.S256F	ACH-000902	Breast Cancer	CCLE	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.S256F	CAL-148	breast	COSMIC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.25
p.S238L	SIDM01175	Other Sarcomas	GDSC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.6556
p.S238L	ACH-002309	Sarcoma	CCLE	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.6556
p.S238L	SW684	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.6556
p.A201V	SIDM00864	Cervical Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.1389
p.A201V	ACH-001341	Cervical Cancer	CCLE	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.1389
p.A201V	DoTc2-4510	cervix	COSMIC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.1389
p.S199L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.0833
p.V227L	SIDM01617	Endometrial Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.0556
p.V227L	SIDM01617	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0556
p.D228H	ACH-000975	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.S198F	CAL-148	breast	COSMIC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.0556
p.S220F	CAL-148	breast	COSMIC	DDSGIGVPSV	DEG_COP1_1	208:217	Mutation rewiring degron network	0.25
p.K228E	NCI-H64	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.K250E	NCI-H64	lung	COSMIC	VGTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM221A

UniProt ID: A4D161

Entrez ID: 340277

Protein name: Protein FAM221A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM221A in