DegronMD

Uniprot ID: A4D161

Source protein: Protein FAM221A

Source gene: FAM221A

Class: DEG_COP1_1

Location: 208:217

E3 ligase: COP1

DEGRON score: 0.7844

ASA_SCORE: 70.21

COIL: 0.8211

CONS_SCORE: 0.4896

DSS_SCORE: 0.2451

HELIX: 0.1621

FCONS_SCORE: 0.9399

RIG_SCORE: 0.7602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V217F	TCGA-77-8133	LUSC	TCGA	DDSGIGVPSV	DEG_COP1_1	0.5957
p.R206W	TCGA-BR-4184	STAD	TCGA	DDSGIGVPSV	DEG_COP1_1	0.2778
p.D208H	TCGA-IQ-7630	HNSC	TCGA	DDSGIGVPSV	DEG_COP1_1	0.7688
p.S221L	DO225037	BRCA	ICGC	DDSGIGVPSV	DEG_COP1_1	0.2222
p.E227A	DO47636	SKCM	ICGC	DDSGIGVPSV	DEG_COP1_1	0.0556
p.A201V	SIDM00864	Cervical Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	0.1389
p.A201V	ACH-001341	Cervical Cancer	CCLE	DDSGIGVPSV	DEG_COP1_1	0.1389
p.A201V	DoTc2-4510	cervix	COSMIC	DDSGIGVPSV	DEG_COP1_1	0.1389
p.S199L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	0.0833
p.V227L	SIDM01617	Endometrial Carcinoma	GDSC	DDSGIGVPSV	DEG_COP1_1	0.0556
p.S198F	CAL-148	breast	COSMIC	DDSGIGVPSV	DEG_COP1_1	0.0556
p.S220F	CAL-148	breast	COSMIC	DDSGIGVPSV	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D161	Protein FAM221A	DEG_COP1_1	208:217	DDSGIGVPSV	COP1	0.7844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons