DegronMD - Q6ZVC0(NYAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q194K	TCGA-06-2557	GBM	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.6944
p.P184S	TCGA-21-1079	LUSC	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0833
p.G571W	TCGA-43-7656	LUSC	TCGA	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1389
p.P192L	TCGA-69-A59K	LUAD	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.3056
p.P192L	DO45335	LUAD	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.3056
p.E322Q	TCGA-77-7141	LUSC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1944
p.G570V	TCGA-86-8073	LUAD	TCGA	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.G570V	DO228226	LICA	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.G570V	DO23624	LUAD	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.Q194P	TCGA-B5-A1MR	UCEC	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.7035
p.Q194P	DO41758	UCEC	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.7035
p.S305L	TCGA-BF-AAP2	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1944
p.S305L	DO219466	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1944
p.V202I	TCGA-BH-A0HF	BRCA	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.3056
p.V202I	DO1749	BRCA	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.3056
p.S536R	TCGA-BR-8382	STAD	TCGA	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1111
p.S536R	DO47925	STAD	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1111
p.K317N	TCGA-CD-8527	STAD	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6918
p.E565G	TCGA-CK-4951	COAD	TCGA	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.E565G	DO10582	COAD	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.R201Q	TCGA-CV-7099	HNSC	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.7329
p.R201Q	TCGA-D5-6540	COAD	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.7329
p.R301H	TCGA-CV-A45O	HNSC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.0833
p.R301H	SIDM00099	Mesothelioma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.0833
p.R301H	ACH-002128	Lung Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.0833
p.R301H	H2722	pleura	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.0833
p.A569T	TCGA-D3-A2JD	SKCM	TCGA	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1944
p.G313R	TCGA-D3-A8GL	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6457
p.L537F	TCGA-DA-A95Z	SKCM	TCGA	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1389
p.L537F	DO219481	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1389
p.R187Q	TCGA-DS-A1OB	CESC	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.1667
p.R560I	TCGA-E6-A1LX	UCEC	TCGA	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.R560I	TCGA-E6-A1LX	UCEC	TCGA	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.D539N	TCGA-EB-A41A	SKCM	TCGA	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1944
p.D539N	DO37429	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1944
p.D539N	DO37406	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1944
p.P320S	TCGA-EE-A2MJ	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.P320S	TCGA-FW-A3R5	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.P320S	SIDM00039	Ovarian Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.P320S	ACH-001569	Skin Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.P320L	TCGA-EE-A3AF	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.P320L	DO37911	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.25
p.V542L	TCGA-EL-A3MX	THCA	TCGA	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.2778
p.V542L	DO49028	THCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.2778
p.T316A	TCGA-ER-A2ND	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6028
p.T316A	DO47449	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6028
p.C321Y	TCGA-FI-A2D5	UCEC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2222
p.C321Y	DO41331	UCEC	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2222
p.R310W	TCGA-FP-A4BE	STAD	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.7523
p.R310W	DO48016	STAD	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.7523
p.G183D	TCGA-KN-8428	KICH	TCGA	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0556
p.R323W	DO7810	COAD	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1667
p.R323W	OCUB-M	breast	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1667
p.P187Q	DO234232	ESAD	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.1667
p.S547F	DO233899	GACA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7982
p.A193V	DO11854	GBM	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation altering degron motif	0.6936
p.T325M	DO11962	GBM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1111
p.G566C	DO49031	HNSC	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.V551F	DO229027	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation blocking phosphorylation signal	0.75
p.V551F	DO229027	LICA	ICGC	PPAY	ITCH	561:564	Mutation blocking phosphorylation signal	0.5
p.A549S	DO229034	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7588
p.A555T	DO229047	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1944
p.A555T	DO229047	LICA	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.P186S	DO229135	LMS	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.1389
p.G540W	DO24596	LUAD	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.2222
p.G540W	DO41999	UCEC	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.2222
p.G183V	DO45402	LUAD	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0556
p.Q534H	DO26959	LUSC	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.G184S	DO220881	MELA	ICGC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0833
p.KE307KK	DO222402	MELA	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0
p.A567T	DO51407	PRAD	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.25
p.Y551S	DO229485	SKCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation blocking phosphorylation signal	0.75
p.Y551S	DO229485	SKCA	ICGC	PPAY	ITCH	561:564	Mutation blocking phosphorylation signal	0.5
p.Y551S	DO227681	SKCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation blocking phosphorylation signal	0.75
p.Y551S	DO227681	SKCA	ICGC	PPAY	ITCH	561:564	Mutation blocking phosphorylation signal	0.5
p.H550L	DO37547	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7313
p.E322K	DO37406	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1944
p.L303I	DO47712	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1389
p.E308K	DO47419	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2778
p.E308K	DO51259	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2778
p.R321Q	DO47419	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2222
p.E561K	DO47368	SKCM	ICGC	PPAY	ITCH	561:564	Mutation altering degron motif	0.7022
p.G537R	DO37936	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.1389
p.F570S	DO43971	UCEC	ICGC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.E565D	SIDM00845	Burkitt's Lymphoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.E565D	SIDM01519	Head and Neck Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.E565D	ACH-000786	Lymphoma	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.3056
p.P562T	SIDM00953	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation altering degron motif	0.7031
p.P562T	ACH-001049	Lung Cancer	CCLE	PPAY	ITCH	561:564	Mutation altering degron motif	0.7031
p.P562T	CPC-N	lung	COSMIC	PPAY	ITCH	561:564	Mutation altering degron motif	0.7031
p.N190I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.25
p.N190I	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.25
p.G570E	SIDM00282	Colorectal Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.G570E	ACH-000998	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.G570E	ACH-001407	Bladder Cancer	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.G570E	CW-2	large intestine	COSMIC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1667
p.D312N	SIDM00562	Breast Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6932
p.D312N	ACH-002163	Breast Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6932
p.D312N	MRK-nu-1	breast	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation altering degron motif	0.6932
p.P534L	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.P534L	ACH-000837	Lung Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.P534L	NCI-H322M	lung	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.P547A	SIDM00934	Pancreatic Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7503
p.P547A	ACH-000354	Pancreatic Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7503
p.P547A	CAPAN-1	pancreas	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation altering degron motif	0.7503
p.V572L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.V572A	SIDM00683	Prostate Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.V572A	ACH-000977	lymph node	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.V572A	LNCaP-Clone-FGC	prostate	COSMIC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.A210S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0833
p.A210S	ACH-000627	Lung Cancer	CCLE	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0833
p.A210S	LCLC-103H	lung	COSMIC	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.0833
p.S566N	SIDM00003	Melanoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.S566N	ACH-000884	Skin Cancer	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.S566N	ACH-002159	Skin Cancer	CCLE	PPAY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.S566N	M14	skin	COSMIC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.2778
p.P534S	SIDM00527	Colorectal Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.P534S	ACH-000935	Colon/Colorectal Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.P534S	MDST8	large intestine	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0556
p.V572M	SIDM00989	Bladder Carcinoma	GDSC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.V572M	BFTC-905	urinary tract	COSMIC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111
p.P561S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	561:564	Mutation altering degron motif	0.6752
p.P561S	ACH-001127	Leukemia	CCLE	PPAY	ITCH	561:564	Mutation altering degron motif	0.6752
p.P561S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	561:564	Mutation altering degron motif	0.6752
p.R302H	SIDM01770	Gastric Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1111
p.R302H	ACH-000908	Gastric Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1111
p.P324S	SIDM00011	Melanoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1389
p.P324S	ACH-000477	Skin Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.1389
p.H535N	ACH-000548	Head and Neck Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0833
p.H535N	BHY	upper aerodigestive tract	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	544:550	Mutation rewiring degron network	0.0833
p.L191V	ACH-001853	Bile Duct Cancer	CCLE	LQRLTRGSR	SCF_FBXL2	193:201	Mutation rewiring degron network	0.2778
p.S306F	KM12	large intestine	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	310:317	Mutation rewiring degron network	0.2222
p.A568E	SKN	soft tissue	COSMIC	PPAY	ITCH	561:564	Mutation substituting flanking lysine	0.3333
p.V572G	NCI-H1876	lung	COSMIC	PPAY	ITCH	561:564	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NYAP1

UniProt ID: Q6ZVC0

Entrez ID: 222950

Protein name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NYAP1 in