DegronMD

Uniprot ID: Q6ZVC0

Source protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

Source gene: NYAP1

Class: DEG_SCF_SKP2-CKS1_1

Location: 310:317

E3 ligase: SKP2,CSK1

DEGRON score: 0.7452

ASA_SCORE: 112.2125

COIL: 0.9573

CONS_SCORE: 0.5977

DSS_SCORE: 0.7989

HELIX: 0.0176

FCONS_SCORE: 0.8454

RIG_SCORE: 0.5291

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E322Q	TCGA-77-7141	LUSC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S305L	TCGA-BF-AAP2	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S305L	DO219466	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K317N	TCGA-CD-8527	STAD	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6918
p.R301H	TCGA-CV-A45O	HNSC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R301H	SIDM00099	Mesothelioma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R301H	ACH-002128	Lung Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R301H	H2722	pleura	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G313R	TCGA-D3-A8GL	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6457
p.P320S	TCGA-EE-A2MJ	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P320S	TCGA-FW-A3R5	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P320S	SIDM00039	Ovarian Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P320S	ACH-001569	Skin Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P320L	TCGA-EE-A3AF	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P320L	DO37911	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.T316A	TCGA-ER-A2ND	SKCM	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6028
p.T316A	DO47449	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6028
p.C321Y	TCGA-FI-A2D5	UCEC	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.C321Y	DO41331	UCEC	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.R310W	TCGA-FP-A4BE	STAD	TCGA	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.7523
p.R310W	DO48016	STAD	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.7523
p.R323W	DO7810	COAD	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R323W	OCUB-M	breast	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T325M	DO11962	GBM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.KE307KK	DO222402	MELA	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0
p.E322K	DO37406	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.L303I	DO47712	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E308K	DO47419	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E308K	DO51259	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R321Q	DO47419	SKCM	ICGC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D312N	SIDM00562	Breast Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D312N	ACH-002163	Breast Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D312N	MRK-nu-1	breast	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.6932
p.R302H	SIDM01770	Gastric Carcinoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R302H	ACH-000908	Gastric Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P324S	SIDM00011	Melanoma	GDSC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P324S	ACH-000477	Skin Cancer	CCLE	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S306F	KM12	large_intestine	COSMIC	RRDGTPTK	DEG_SCF_SKP2-CKS1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRDGTPTK

Degron related mutations and impact score

Drug responses associated with NYAP1 mutations

All proteins holding degron of RRDGTPTK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	DEG_SCF_SKP2-CKS1_1	310:317	RRDGTPTK	SKP2,CSK1	0.7452	More...