DegronMD

Uniprot ID: Q6ZVC0

Source protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

Source gene: NYAP1

Class: SCF_FBXL2

Location: 193:201

E3 ligase: FBXL2

DEGRON score: 0.7863

ASA_SCORE: 105.5

COIL: 0.8362

CONS_SCORE: 0.4402

DSS_SCORE: 0.6138

HELIX: 0.1471

FCONS_SCORE: 0.7688

RIG_SCORE: 0.696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q194K	TCGA-06-2557	GBM	TCGA	LQRLTRGSR	SCF_FBXL2	0.6944
p.P184S	TCGA-21-1079	LUSC	TCGA	LQRLTRGSR	SCF_FBXL2	0.0833
p.P192L	TCGA-69-A59K	LUAD	TCGA	LQRLTRGSR	SCF_FBXL2	0.3056
p.P192L	DO45335	LUAD	ICGC	LQRLTRGSR	SCF_FBXL2	0.3056
p.Q194P	TCGA-B5-A1MR	UCEC	TCGA	LQRLTRGSR	SCF_FBXL2	0.7035
p.Q194P	DO41758	UCEC	ICGC	LQRLTRGSR	SCF_FBXL2	0.7035
p.V202I	TCGA-BH-A0HF	BRCA	TCGA	LQRLTRGSR	SCF_FBXL2	0.3056
p.V202I	DO1749	BRCA	ICGC	LQRLTRGSR	SCF_FBXL2	0.3056
p.R201Q	TCGA-CV-7099	HNSC	TCGA	LQRLTRGSR	SCF_FBXL2	0.7329
p.R201Q	TCGA-D5-6540	COAD	TCGA	LQRLTRGSR	SCF_FBXL2	0.7329
p.R187Q	TCGA-DS-A1OB	CESC	TCGA	LQRLTRGSR	SCF_FBXL2	0.1667
p.G183D	TCGA-KN-8428	KICH	TCGA	LQRLTRGSR	SCF_FBXL2	0.0556
p.P187Q	DO234232	ESAD	ICGC	LQRLTRGSR	SCF_FBXL2	0.1667
p.A193V	DO11854	GBM	ICGC	LQRLTRGSR	SCF_FBXL2	0.6936
p.P186S	DO229135	LMS	ICGC	LQRLTRGSR	SCF_FBXL2	0.1389
p.G183V	DO45402	LUAD	ICGC	LQRLTRGSR	SCF_FBXL2	0.0556
p.G184S	DO220881	MELA	ICGC	LQRLTRGSR	SCF_FBXL2	0.0833
p.N190I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LQRLTRGSR	SCF_FBXL2	0.25
p.N190I	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LQRLTRGSR	SCF_FBXL2	0.25
p.A210S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	LQRLTRGSR	SCF_FBXL2	0.0833
p.A210S	ACH-000627	Lung Cancer	CCLE	LQRLTRGSR	SCF_FBXL2	0.0833
p.A210S	LCLC-103H	lung	COSMIC	LQRLTRGSR	SCF_FBXL2	0.0833
p.L191V	ACH-001853	Bile Duct Cancer	CCLE	LQRLTRGSR	SCF_FBXL2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	SCF_FBXL2	193:201	LQRLTRGSR	FBXL2	0.7863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons