DegronMD

Uniprot ID: Q6ZVC0

Source protein: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

Source gene: NYAP1

Class: DEG_SCF_FBW7_1

Location: 544:550

E3 ligase: FBXW7

DEGRON score: 0.8496

ASA_SCORE: 90.9429

COIL: 0.9023

CONS_SCORE: 0.6725

DSS_SCORE: 0.3195

HELIX: 0.0469

FCONS_SCORE: 1.0338

RIG_SCORE: 0.7829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S536R	TCGA-BR-8382	STAD	TCGA	PLTPLWT	DEG_SCF_FBW7_1	0.1111
p.S536R	DO47925	STAD	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1111
p.L537F	TCGA-DA-A95Z	SKCM	TCGA	PLTPLWT	DEG_SCF_FBW7_1	0.1389
p.L537F	DO219481	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1389
p.R560I	TCGA-E6-A1LX	UCEC	TCGA	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.D539N	TCGA-EB-A41A	SKCM	TCGA	PLTPLWT	DEG_SCF_FBW7_1	0.1944
p.D539N	DO37429	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1944
p.D539N	DO37406	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1944
p.V542L	TCGA-EL-A3MX	THCA	TCGA	PLTPLWT	DEG_SCF_FBW7_1	0.2778
p.V542L	DO49028	THCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.2778
p.S547F	DO233899	GACA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.7982
p.V551F	DO229027	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.75
p.A549S	DO229034	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.7588
p.A555T	DO229047	LICA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1944
p.G540W	DO24596	LUAD	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.2222
p.G540W	DO41999	UCEC	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.2222
p.Q534H	DO26959	LUSC	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.Y551S	DO229485	SKCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.75
p.Y551S	DO227681	SKCA	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.75
p.H550L	DO37547	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.7313
p.G537R	DO37936	SKCM	ICGC	PLTPLWT	DEG_SCF_FBW7_1	0.1389
p.P534L	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.P534L	ACH-000837	Lung Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.P534L	NCI-H322M	lung	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.P547A	SIDM00934	Pancreatic Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	0.7503
p.P547A	ACH-000354	Pancreatic Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	0.7503
p.P547A	CAPAN-1	pancreas	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	0.7503
p.P534S	SIDM00527	Colorectal Carcinoma	GDSC	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.P534S	ACH-000935	Colon/Colorectal Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.P534S	MDST8	large_intestine	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	0.0556
p.H535N	ACH-000548	Head and Neck Cancer	CCLE	PLTPLWT	DEG_SCF_FBW7_1	0.0833
p.H535N	BHY	upper_aerodigestive_tract	COSMIC	PLTPLWT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPLWT

Degron related mutations and impact score

Drug responses associated with NYAP1 mutations

All proteins holding degron of PLTPLWT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	DEG_SCF_FBW7_1	544:550	PLTPLWT	FBXW7	0.8496	More...