DegronMD - P43146(DCC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1343C	TCGA-06-5416	GBM	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.R1343C	DO222884	COCA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.R1343C	DO10880	GBM	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.L1366I	TCGA-06-5416	GBM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.6063
p.L1366I	DO10880	GBM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.6063
p.K1167E	TCGA-22-5489	LUSC	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation substituting flanking lysine	0.1944
p.K1167E	DO26480	LUSC	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation substituting flanking lysine	0.1944
p.G556S	TCGA-33-A4WN	LUSC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.G556S	TCGA-77-7337	LUSC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.G556S	DO27445	LUSC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.G556S	DO219121	LUSC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.H1340Q	TCGA-44-7667	LUAD	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.3056
p.H1340Q	DO23830	LUAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.3056
p.M1162I	TCGA-49-AARO	LUAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	TCGA-BF-A5EP	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	TCGA-EE-A182	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	DO218924	LUAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	DO220895	MELA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	DO37814	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.M1162I	DO223906	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2222
p.P1151H	TCGA-55-8616	LUAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2778
p.P1151H	DO23566	LUAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2778
p.T542I	TCGA-58-A46N	LUSC	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.T542I	TCGA-58-A46N	LUSC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.T542I	DO45460	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.T542I	DO45460	LUSC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1111
p.S1323R	TCGA-85-6798	LUSC	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1111
p.S1323R	DO27295	LUSC	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1111
p.E1324V	TCGA-90-A4EE	LUSC	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1389
p.E1324V	DO45513	LUSC	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1389
p.P1338T	TCGA-95-7043	LUAD	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7031
p.P1338T	DO24739	LUAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7031
p.E1159D	TCGA-A5-A0G2	UCEC	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.E1159D	DO41235	UCEC	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.P1362S	TCGA-A5-A0G2	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.5641
p.P1362S	DO41235	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.5641
p.P528T	TCGA-A6-6653	COAD	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1111
p.P528T	DO10373	COAD	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1111
p.S538F	TCGA-AA-3947	COAD	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7982
p.S538F	TCGA-DA-A1I5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7982
p.S538F	DO8192	COAD	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7982
p.S538F	DO37447	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7982
p.L1366F	TCGA-AJ-A3EK	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.587
p.L1366F	DO41584	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.587
p.R562I	TCGA-AJ-A5DW	UCEC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.R562I	TCGA-ND-A4WC	UCS	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.R562I	DO50075	UCEC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.Q559K	TCGA-AN-A04C	BRCA	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.Q559K	TCGA-D3-A2JB	SKCM	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.Q559K	DO1280	BRCA	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.Q559K	DO47607	SKCM	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.A1346V	TCGA-AP-A051	UCEC	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1389
p.A1346V	DO42673	UCEC	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1389
p.R1343H	TCGA-AP-A054	UCEC	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.R1343H	TCGA-JY-A93E	ESCA	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.R1343H	DO42256	UCEC	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.W1154C	TCGA-AX-A1CE	UCEC	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.5889
p.W1154C	DO42280	UCEC	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.5889
p.H1378R	TCGA-B5-A1MX	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.H1378R	DO41999	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.W1154L	TCGA-BF-A1Q0	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.5904
p.W1154L	DO47374	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.5904
p.S1328I	TCGA-BQ-5877	KIRP	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.25
p.S1328I	DO20859	KIRP	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.25
p.E1161G	TCGA-BR-4361	STAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.E1161G	DO38887	STAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.E1161G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.E1161G	HCC-15	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.T1339A	TCGA-BR-4361	STAD	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.6028
p.T1339A	DO38887	STAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.6028
p.T1333I	TCGA-CC-A3M9	LIHC	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.5966
p.T1333I	DO44946	LIHC	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.5966
p.S1368P	TCGA-CS-6666	LGG	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.6752
p.S1368P	DO22309	LGG	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.6752
p.P1375T	TCGA-CV-A45W	HNSC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375T	DO52060	HNSC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375H	TCGA-CV-A45W	HNSC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375H	DO52060	HNSC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P530Q	TCGA-D3-A2JB	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.P530Q	DO47607	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.R1329K	TCGA-D3-A3CB	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2778
p.R1329K	TCGA-FW-A3R5	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2778
p.R1329K	DO37406	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2778
p.R1329K	DO47386	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2778
p.D1147N	TCGA-D3-A8GM	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.D1147N	TCGA-Z2-A8RT	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.D1147N	DO50288	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.D1147N	DO51301	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.D1147N	SIDM01577	Plasma Cell Myeloma	GDSC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.N555K	TCGA-DQ-5629	HNSC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.2778
p.N555K	DO233906	GACA	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.2778
p.N555K	DO15270	HNSC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.2778
p.P551L	TCGA-DU-8164	LGG	TCGA	PPAY	ITCH	550:553	Mutation altering degron motif	0.7582
p.P551L	DO22560	LGG	ICGC	PPAY	ITCH	550:553	Mutation altering degron motif	0.7582
p.E1161K	TCGA-DX-A8BT	SARC	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.E1161K	DO220063	SARC	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.P1351L	TCGA-EE-A17X	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.P1351L	DO37931	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.E1166K	TCGA-EE-A29E	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.E1166K	DO37831	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1111
p.E1159K	TCGA-EE-A2M5	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.E1159K	DO222423	MELA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.E1159K	DO37425	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.R562T	TCGA-EK-A2RC	CESC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.R562T	DO49945	CESC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.L545R	TCGA-EO-A22U	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	TCGA-EO-A22U	UCEC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545R	TCGA-VQ-A8PC	STAD	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	TCGA-VQ-A8PC	STAD	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545R	DO234214	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	DO234214	ESAD	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545R	DO234449	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	DO234449	ESAD	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545R	DO51767	STAD	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	DO51767	STAD	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545R	DO43755	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545R	DO43755	UCEC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545I	TCGA-EO-A3B0	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545I	TCGA-EO-A3B0	UCEC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.L545I	DO219773	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.L545I	DO219773	UCEC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.E1358K	TCGA-ER-A195	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.25
p.E1358K	TCGA-ER-A42L	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.25
p.E1358K	DO47712	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.25
p.E1358K	DO223910	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.25
p.E1325V	TCGA-F4-6570	COAD	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1667
p.E1325V	DO10443	COAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1667
p.E532D	TCGA-FS-A1ZA	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.E532D	DO37551	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.E549K	TCGA-GF-A6C9	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-GF-A6C9	SKCM	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.E549K	DO51254	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.E549K	DO51254	SKCM	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.E549K	SIDM01175	Other Sarcomas	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.E549K	SIDM01175	Other Sarcomas	GDSC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.E549K	SW684	soft tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.E549K	SW684	soft tissue	COSMIC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.3056
p.S1344N	TCGA-GF-A6C9	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1944
p.S1344N	DO51254	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1944
p.E532K	TCGA-GV-A3JV	BLCA	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.E532K	DO743	BLCA	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.L1148I	TCGA-GV-A3QK	BLCA	TCGA	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1944
p.L1148I	DO563	BLCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1944
p.P1375S	TCGA-IH-A3EA	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375S	TCGA-QB-AA9O	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375S	DO229465	SKCA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375S	DO37667	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1375S	DO51267	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.T1339P	TCGA-L5-A88Y	ESCA	TCGA	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7031
p.T1339P	DO50406	ESAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7031
p.T1339P	DO234260	ESAD	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7031
p.P550S	TCGA-LN-A49M	ESCA	TCGA	PPAY	ITCH	550:553	Mutation altering degron motif	0.6752
p.G560S	TCGA-NI-A4U2	LIHC	TCGA	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.G560S	DO48589	LIHC	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.G560S	DO46568	OV	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.P1353A	TCGA-PD-A5DF	LIHC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1111
p.P1353A	DO52307	LIHC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1111
p.Q526H	TCGA-VR-A8EQ	ESCA	TCGA	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0556
p.M1354I	TCGA-ZF-A9R9	BLCA	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.M1354I	DO219066	BLCA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1389
p.P1353L	DO234350	ESAD	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.1111
p.P551S	DO48244	ESCA	ICGC	PPAY	ITCH	550:553	Mutation altering degron motif	0.6752
p.D1147E	DO233246	GACA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.1667
p.A552V	DO224659	LAML	ICGC	PPAY	ITCH	550:553	Mutation altering degron motif	0.5825
p.A1334S	DO228974	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7588
p.A1346S	DO228971	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1389
p.G560V	DO229018	LICA	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.S1344I	DO229015	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.1944
p.G556C	DO229028	LICA	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.S1321Y	DO229050	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.0556
p.P1150L	DO50970	LICA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.H1378Y	DO50803	LIRI	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.P1327L	DO23520	LIRI	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.2222
p.P1332S	DO229177	LMS	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.6752
p.P1351S	DO220903	MELA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation rewiring degron network	0.0556
p.P1348S	DO222420	MELA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.0833
p.P1332H	DO49420	PACA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation altering degron motif	0.7694
p.S543L	DO219878	SKCA	ICGC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.25
p.S543L	DO219878	SKCA	ICGC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.D1152N	DO229462	SKCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.3056
p.P1348L	DO218850	SKCA	ICGC	IPTACVRPT	DEG_SIAH_1	1331:1339	Mutation rewiring degron network	0.0833
p.Q535H	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.Q535H	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.Q535H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.Q535H	SIDM01519	Head and Neck Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.Q535H	Daudi	haematopoietic and lymphoid tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.H1156N	SIDM00652	Small Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.7423
p.H1156N	NCI-H1105	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.7423
p.G1143C	SIDM00223	Small Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0556
p.G1143C	IST-SL1	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0556
p.V527I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.V527I	EBC-1	lung	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.S1144I	SIDM00410	Other Blood Cancers	GDSC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0833
p.S1144I	YT	haematopoietic and lymphoid tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.0833
p.A552D	SIDM00699	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	550:553	Mutation altering degron motif	0.6682
p.A552D	NCI-H2141	lung	COSMIC	PPAY	ITCH	550:553	Mutation altering degron motif	0.6682
p.T539A	SIDM01588	Endometrial Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.7139
p.M556T	ACH-000706	Lung Cancer	CCLE	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.M556T	EKVX	lung	COSMIC	PPAY	ITCH	550:553	Mutation rewiring degron network	0.25
p.M550I	ACH-000845	Lung Cancer	CCLE	PPAY	ITCH	550:553	Mutation altering degron motif	0.7618
p.Y530C	ACH-000997	Colon/Colorectal Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.Y530C	HCT-15	large intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.E526K	SW684	soft tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0556
p.A1151S	BALL-1	haematopoietic and lymphoid tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.2778
p.A529D	NCI-H2141	lung	COSMIC	AVSTS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1389
p.D1154N	LOXIMVI	skin	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation altering degron motif	0.6932
p.P1150T	SNU-81	large intestine	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1153:1158	Mutation rewiring degron network	0.25
p.V1376M	KMH-2	thyroid	COSMIC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation substituting flanking lysine	0.2222
p.L1361I	H513	pleura	COSMIC	VPYTPLLS	DEG_SCF_FBW7_1	1361:1368	Mutation altering degron motif	0.7174

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCC

UniProt ID: P43146

Entrez ID: 1630

Protein name: Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCC in