DegronMD

Uniprot ID: P43146

Source protein: Netrin receptor DCC

Source gene: DCC

Class: DEG_SIAH_1

Location: 1331:1339

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9672

ASA_SCORE: 86.2222

COIL: 0.9168

CONS_SCORE: 0.482

DSS_SCORE: 0.6029

HELIX: 0.0498

FCONS_SCORE: 0.9085

RIG_SCORE: 0.6735

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1343C	TCGA-06-5416	GBM	TCGA	IPTACVRPT	DEG_SIAH_1	0.2222
p.R1343C	DO222884	COCA	ICGC	IPTACVRPT	DEG_SIAH_1	0.2222
p.R1343C	DO10880	GBM	ICGC	IPTACVRPT	DEG_SIAH_1	0.2222
p.H1340Q	TCGA-44-7667	LUAD	TCGA	IPTACVRPT	DEG_SIAH_1	0.3056
p.H1340Q	DO23830	LUAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.3056
p.S1323R	TCGA-85-6798	LUSC	TCGA	IPTACVRPT	DEG_SIAH_1	0.1111
p.S1323R	DO27295	LUSC	ICGC	IPTACVRPT	DEG_SIAH_1	0.1111
p.E1324V	TCGA-90-A4EE	LUSC	TCGA	IPTACVRPT	DEG_SIAH_1	0.1389
p.E1324V	DO45513	LUSC	ICGC	IPTACVRPT	DEG_SIAH_1	0.1389
p.P1338T	TCGA-95-7043	LUAD	TCGA	IPTACVRPT	DEG_SIAH_1	0.7031
p.P1338T	DO24739	LUAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.7031
p.A1346V	TCGA-AP-A051	UCEC	TCGA	IPTACVRPT	DEG_SIAH_1	0.1389
p.A1346V	DO42673	UCEC	ICGC	IPTACVRPT	DEG_SIAH_1	0.1389
p.R1343H	TCGA-AP-A054	UCEC	TCGA	IPTACVRPT	DEG_SIAH_1	0.2222
p.R1343H	TCGA-JY-A93E	ESCA	TCGA	IPTACVRPT	DEG_SIAH_1	0.2222
p.R1343H	DO42256	UCEC	ICGC	IPTACVRPT	DEG_SIAH_1	0.2222
p.S1328I	TCGA-BQ-5877	KIRP	TCGA	IPTACVRPT	DEG_SIAH_1	0.25
p.S1328I	DO20859	KIRP	ICGC	IPTACVRPT	DEG_SIAH_1	0.25
p.T1339A	TCGA-BR-4361	STAD	TCGA	IPTACVRPT	DEG_SIAH_1	0.6028
p.T1339A	DO38887	STAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.6028
p.T1333I	TCGA-CC-A3M9	LIHC	TCGA	IPTACVRPT	DEG_SIAH_1	0.5966
p.T1333I	DO44946	LIHC	ICGC	IPTACVRPT	DEG_SIAH_1	0.5966
p.R1329K	TCGA-D3-A3CB	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	0.2778
p.R1329K	TCGA-FW-A3R5	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	0.2778
p.R1329K	DO37406	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	0.2778
p.R1329K	DO47386	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	0.2778
p.E1325V	TCGA-F4-6570	COAD	TCGA	IPTACVRPT	DEG_SIAH_1	0.1667
p.E1325V	DO10443	COAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.1667
p.S1344N	TCGA-GF-A6C9	SKCM	TCGA	IPTACVRPT	DEG_SIAH_1	0.1944
p.S1344N	DO51254	SKCM	ICGC	IPTACVRPT	DEG_SIAH_1	0.1944
p.T1339P	TCGA-L5-A88Y	ESCA	TCGA	IPTACVRPT	DEG_SIAH_1	0.7031
p.T1339P	DO50406	ESAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.7031
p.T1339P	DO234260	ESAD	ICGC	IPTACVRPT	DEG_SIAH_1	0.7031
p.A1334S	DO228974	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	0.7588
p.A1346S	DO228971	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	0.1389
p.S1344I	DO229015	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	0.1944
p.S1321Y	DO229050	LICA	ICGC	IPTACVRPT	DEG_SIAH_1	0.0556
p.P1327L	DO23520	LIRI	ICGC	IPTACVRPT	DEG_SIAH_1	0.2222
p.P1332S	DO229177	LMS	ICGC	IPTACVRPT	DEG_SIAH_1	0.6752
p.P1348S	DO222420	MELA	ICGC	IPTACVRPT	DEG_SIAH_1	0.0833
p.P1332H	DO49420	PACA	ICGC	IPTACVRPT	DEG_SIAH_1	0.7694
p.P1348L	DO218850	SKCA	ICGC	IPTACVRPT	DEG_SIAH_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPTACVRPT

Degron related mutations and impact score

Drug responses associated with DCC mutations

All proteins holding degron of IPTACVRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43146	Netrin receptor DCC	DEG_SIAH_1	1331:1339	IPTACVRPT	SIAH1,SIAH2,SIAH3	0.9672	More...