DegronMD

Uniprot ID: P43146

Source protein: Netrin receptor DCC

Source gene: DCC

Class: DEG_SPOP_SBC_1

Location: 536:540

E3 ligase: SPOP

DEGRON score: 0.6288

ASA_SCORE: 46.18

COIL: 0.3296

CONS_SCORE: 0.5757

DSS_SCORE: 0.3848

HELIX: 0.0026

FCONS_SCORE: 0.9281

RIG_SCORE: 0.7301

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T542I	TCGA-58-A46N	LUSC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2778
p.T542I	DO45460	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2778
p.P528T	TCGA-A6-6653	COAD	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1111
p.P528T	DO10373	COAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1111
p.S538F	TCGA-AA-3947	COAD	TCGA	AVSTS	DEG_SPOP_SBC_1	0.7982
p.S538F	TCGA-DA-A1I5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.7982
p.S538F	DO8192	COAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7982
p.S538F	DO37447	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7982
p.P530Q	TCGA-D3-A2JB	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1667
p.P530Q	DO47607	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.L545R	TCGA-EO-A22U	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545R	TCGA-VQ-A8PC	STAD	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545R	DO234214	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545R	DO234449	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545R	DO51767	STAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545R	DO43755	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545I	TCGA-EO-A3B0	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1944
p.L545I	DO219773	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.E532D	TCGA-FS-A1ZA	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2222
p.E532D	DO37551	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2222
p.E549K	TCGA-GF-A6C9	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.0833
p.E549K	DO51254	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.E549K	SIDM01175	Other Sarcomas	GDSC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.E549K	SW684	soft_tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.E532K	TCGA-GV-A3JV	BLCA	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2222
p.E532K	DO743	BLCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2222
p.Q526H	TCGA-VR-A8EQ	ESCA	TCGA	AVSTS	DEG_SPOP_SBC_1	0.0556
p.S543L	DO219878	SKCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.25
p.Q535H	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.Q535H	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.Q535H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.Q535H	SIDM01519	Head and Neck Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.Q535H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.V527I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.V527I	EBC-1	lung	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.T539A	SIDM01588	Endometrial Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.7139
p.Y530C	ACH-000997	Colon/Colorectal Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	0.1667
p.Y530C	HCT-15	large_intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.E526K	SW684	soft_tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.0556
p.A529D	NCI-H2141	lung	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	269:273	AVSTS	SPOP	0.9767	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	107:111	AVSTS	SPOP	0.7984	More...
P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	DEG_SPOP_SBC_1	20:24	AVSTS	SPOP	0.9441	More...
P43146	Netrin receptor DCC	DEG_SPOP_SBC_1	536:540	AVSTS	SPOP	0.6288	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	397:401	AVSTS	SPOP	0.9758	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SPOP_SBC_1	337:341	AVSTS	SPOP	0.9472	More...
Q9H2F9	Coiled-coil domain-containing protein 68	DEG_SPOP_SBC_1	313:317	AVSTS	SPOP	0.9865	More...
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SPOP_SBC_1	816:820	AVSTS	SPOP	0.6394	More...
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	DEG_SPOP_SBC_1	276:280	AVSTS	SPOP	0.9612	More...
Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	DEG_SPOP_SBC_1	271:275	AVSTS	SPOP	0.9672	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SPOP_SBC_1	55:59	AVSTS	SPOP	0.8176	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	16:20	AVSTS	SPOP	0.7143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSTS

Degron related mutations and impact score

Drug responses associated with DCC mutations

All proteins holding degron of AVSTS