DegronMD

Uniprot ID: Q9H2F9

Source protein: Coiled-coil domain-containing protein 68

Source gene: CCDC68

Class: DEG_SPOP_SBC_1

Location: 313:317

E3 ligase: SPOP

DEGRON score: 0.9865

ASA_SCORE: 74.22

COIL: 0.691

CONS_SCORE: 0.7276

DSS_SCORE: 0.4582

HELIX: 0.0568

FCONS_SCORE: 0.9916

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T321N	TCGA-18-4083	LUSC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2222
p.T321N	DO229038	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2222
p.T321N	DO26504	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2222
p.T316I	TCGA-B0-5115	KIRC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.7078
p.T316I	DO18761	KIRC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7078
p.S317I	TCGA-EO-A22R	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.7341
p.S317I	TCGA-FS-A1ZR	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.7341
p.S317I	DO37651	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7341
p.S317I	DO42713	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7341
p.S325Y	TCGA-FW-A3R5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1111
p.S325Y	DO37406	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1111
p.V310I	TCGA-FW-A3R5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.25
p.V310I	DO37406	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.25
p.V310I	SIDM00999	Bladder Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.25
p.V310I	ACH-000973	Bladder Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	0.25
p.V310I	639-V	urinary_tract	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.25
p.S325F	TCGA-YD-A89C	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1111
p.S325F	DO219501	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1111
p.E322K	DO234192	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.S317R	DO233652	GACA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7427
p.V324A	SIDM00567	Other Solid Cancers	GDSC	AVSTS	DEG_SPOP_SBC_1	0.1389
p.V324A	ACH-000776	Brain Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	0.1389
p.V324A	ONS-76	central_nervous_system	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1389
p.K309N	SIDM01066	Melanoma	GDSC	AVSTS	DEG_SPOP_SBC_1	0.3333
p.K309N	ACH-000650	Skin Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	0.3333
p.K309N	IGR-37	skin	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	269:273	AVSTS	SPOP	0.9767	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	107:111	AVSTS	SPOP	0.7984	More...
P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	DEG_SPOP_SBC_1	20:24	AVSTS	SPOP	0.9441	More...
P43146	Netrin receptor DCC	DEG_SPOP_SBC_1	536:540	AVSTS	SPOP	0.6288	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	397:401	AVSTS	SPOP	0.9758	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SPOP_SBC_1	337:341	AVSTS	SPOP	0.9472	More...
Q9H2F9	Coiled-coil domain-containing protein 68	DEG_SPOP_SBC_1	313:317	AVSTS	SPOP	0.9865	More...
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SPOP_SBC_1	816:820	AVSTS	SPOP	0.6394	More...
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	DEG_SPOP_SBC_1	276:280	AVSTS	SPOP	0.9612	More...
Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	DEG_SPOP_SBC_1	271:275	AVSTS	SPOP	0.9672	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SPOP_SBC_1	55:59	AVSTS	SPOP	0.8176	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	16:20	AVSTS	SPOP	0.7143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons