DegronMD - Q9H2F9(CCDC68)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T321N	TCGA-18-4083	LUSC	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2222
p.T321N	DO229038	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2222
p.T321N	DO26504	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.2222
p.T316I	TCGA-B0-5115	KIRC	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7078
p.T316I	DO18761	KIRC	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7078
p.S317I	TCGA-EO-A22R	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7341
p.S317I	TCGA-FS-A1ZR	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7341
p.S317I	DO37651	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7341
p.S317I	DO42713	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7341
p.S325Y	TCGA-FW-A3R5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.S325Y	DO37406	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.V310I	TCGA-FW-A3R5	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.V310I	DO37406	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.V310I	SIDM00999	Bladder Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.V310I	ACH-000973	Bladder Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.V310I	639-V	urinary tract	COSMIC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.S325F	TCGA-YD-A89C	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.S325F	DO219501	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.E322K	DO234192	ESAD	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1944
p.S317R	DO233652	GACA	ICGC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7427
p.V324A	SIDM00567	Other Solid Cancers	GDSC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.V324A	ACH-000776	Brain Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.V324A	ONS-76	central nervous system	COSMIC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.K309N	SIDM01066	Melanoma	GDSC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation substituting flanking lysine	0.3333
p.K309N	ACH-000650	Skin Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation substituting flanking lysine	0.3333
p.K309N	IGR-37	skin	COSMIC	AVSTS	DEG_SPOP_SBC_1	313:317	Mutation substituting flanking lysine	0.3333

Kaplan plot for CCDC68 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC68

UniProt ID: Q9H2F9

Entrez ID: 80323

Protein name: Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC68 in