DegronMD - Q9BQQ3(GORASP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P218L	TCGA-85-6561	LUSC	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation altering degron motif	0.6471
p.S348Y	TCGA-AP-A056	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.K211N	TCGA-CA-6717	COAD	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.2778
p.K211N	TCGA-CA-6717	COAD	TCGA	PPSY	ITCH	206:209	Mutation rewiring degron network	0.2778
p.K211N	SIDM00193	Colorectal Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.2778
p.K211N	SIDM00193	Colorectal Carcinoma	GDSC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.2778
p.K211N	SNU-81	large intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.2778
p.K211N	SNU-81	large intestine	COSMIC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.2778
p.G215D	TCGA-CG-5733	STAD	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation altering degron motif	0.6087
p.G215D	TCGA-K4-A4AC	BLCA	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation altering degron motif	0.6087
p.L333P	TCGA-D8-A1XK	BRCA	TCGA	AVSTS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.P203Q	TCGA-DA-A1I1	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.0556
p.P203Q	TCGA-DA-A1I1	SKCM	TCGA	PPSY	ITCH	206:209	Mutation rewiring degron network	0.25
p.P207H	TCGA-EE-A2GT	SKCM	TCGA	PPSY	ITCH	206:209	Mutation altering degron motif	0.7694
p.G197W	TCGA-ER-A19Q	SKCM	TCGA	PPSY	ITCH	206:209	Mutation rewiring degron network	0.0833
p.G197W	DO47497	SKCM	ICGC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.0833
p.A249T	DO8858	COAD	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation rewiring degron network	0.1111
p.D235E	DO228986	LICA	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation altering degron motif	0.6758
p.A204D	DO229015	LICA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation blocking phosphorylation signal	0.5278
p.A204D	DO229015	LICA	ICGC	PPSY	ITCH	206:209	Mutation blocking phosphorylation signal	0.7222
p.A241D	DO229027	LICA	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation altering degron motif	0.7793
p.E203D	DO37405	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.0556
p.E203D	DO37405	SKCM	ICGC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.25
p.L231P	DO43178	UCEC	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation rewiring degron network	0.25
p.T232I	DO41199	UCEC	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation rewiring degron network	0.2778
p.T340P	SIDM02024	Esophageal Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7031
p.Y198F	SIDM00789	Colorectal Carcinoma	GDSC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.1111
p.Y198F	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	206:209	Mutation rewiring degron network	0.1111
p.S208R	SIDM00948	Burkitt's Lymphoma	GDSC	PPSY	ITCH	206:209	Mutation altering degron motif	0.6316
p.S208R	DG-75	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	206:209	Mutation altering degron motif	0.6316
p.R201Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.R201Q	ACH-000925	Lung Cancer	CCLE	PPSY	ITCH	206:209	Mutation rewiring degron network	0.1944
p.S341L	SIDM00011	Melanoma	GDSC	AVSTS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7667
p.E239K	SIDM01559	Melanoma	GDSC	PGPTPEDS	DEG_SCF_FBW7_1	234:241	Mutation altering degron motif	0.591
p.F211L	ACH-002274	Leukemia	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.2778
p.F211L	ACH-002274	Leukemia	CCLE	PPSY	ITCH	206:209	Mutation rewiring degron network	0.2778
p.F211L	MLMA	haematopoietic and lymphoid tissue	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation rewiring degron network	0.2778
p.F211L	MLMA	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	206:209	Mutation rewiring degron network	0.2778
p.S216L	HCC2998	large intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	213:220	Mutation altering degron motif	0.7667

Kaplan plot for GORASP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GORASP1

UniProt ID: Q9BQQ3

Entrez ID: 64689

Protein name: Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GORASP1 in