DegronMD

Uniprot ID: Q9BQQ3

Source protein: Golgi reassembly-stacking protein 1

Source gene: GORASP1

Class: DEG_SCF_FBW7_1

Location: 213:220

E3 ligase: FBXW7

DEGRON score: 0.968

ASA_SCORE: 83

COIL: 0.9659

CONS_SCORE: 0.2587

DSS_SCORE: 0.7546

HELIX: 0.0174

FCONS_SCORE: 0.8563

RIG_SCORE: 0.4979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P218L	TCGA-85-6561	LUSC	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.6471
p.K211N	TCGA-CA-6717	COAD	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.K211N	SIDM00193	Colorectal Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.K211N	SNU-81	large_intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.G215D	TCGA-CG-5733	STAD	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.6087
p.G215D	TCGA-K4-A4AC	BLCA	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.6087
p.P203Q	TCGA-DA-A1I1	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.0556
p.A204D	DO229015	LICA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.5278
p.E203D	DO37405	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.0556
p.F211L	ACH-002274	Leukemia	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.F211L	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.S216L	HCC2998	large_intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VAB6	Kinase suppressor of Ras 2	DEG_SCF_FBW7_1	287:294	PPGTPPPS	FBXW7	0.9991	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SCF_FBW7_1	213:220	PPGTPPPS	FBXW7	0.968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons