DegronMD

Uniprot ID: Q6VAB6

Source protein: Kinase suppressor of Ras 2

Source gene: KSR2

Class: DEG_SCF_FBW7_1

Location: 287:294

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 76.5

COIL: 0.9601

CONS_SCORE: 0.4508

DSS_SCORE: 0.7744

HELIX: 0.0176

FCONS_SCORE: 1.329

RIG_SCORE: 0.5534

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S294F	TCGA-D3-A8GI	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.9093
p.S294F	TCGA-GF-A3OT	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.9093
p.S294F	DO47288	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.9093
p.S294F	DO50284	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.9093
p.R296Q	TCGA-EE-A29D	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.R296Q	DO220902	MELA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.R296Q	DO38123	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.L301S	TCGA-F7-A624	HNSC	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.1389
p.G289E	TCGA-FS-A1ZW	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.6087
p.G304E	TCGA-YG-AA3N	SKCM	TCGA	PPGTPPPS	DEG_SCF_FBW7_1	0.0556
p.P299H	DO7922	COAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.1944
p.S284Y	DO222492	COCA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.3611
p.T298M	DO50436	ESAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2222
p.T298M	DO234389	ESAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2222
p.T298M	DO49060	HNSC	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2222
p.P303L	DO233058	GACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.0833
p.H280Y	DO233641	GACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.1389
p.D294E	DO229009	LICA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.D294E	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.D294E	SIDM00426	Rhabdomyosarcoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.D294E	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.D294E	SIDM00871	Non-Cancerous	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.D294E	SIDM00872	Breast Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.6758
p.S282N	DO23633	LUAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.3056
p.R280K	DO51474	PACA	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.1389
p.K281T	DO230589	PRAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.P299S	DO48550	SKCM	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.1944
p.A278V	DO38475	STAD	ICGC	PPGTPPPS	DEG_SCF_FBW7_1	0.0833
p.A278V	SIDM02051	Colorectal Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.0833
p.R281W	SIDM00684	Glioblastoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.R281W	LN-229	central_nervous_system	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.2778
p.E295K	SIDM00337	Melanoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.3056
p.E295K	MEL-HO	skin	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.3056
p.R292L	SIDM00719	Small Cell Lung Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.8428
p.R292L	NCI-H345	lung	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.8428
p.R292H	SIDM00683	Prostate Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.8244
p.R292H	LNCaP-Clone-FGC	prostate	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.8244
p.S284F	SIDM00251	Gastric Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.3611
p.S284F	TGBC11TKB	stomach	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.3611
p.A278T	SIDM01612	Endometrial Carcinoma	GDSC	PPGTPPPS	DEG_SCF_FBW7_1	0.0833
p.P293L	ACH-000969	Colon/Colorectal Cancer	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	0.6471
p.P293L	KM12	large_intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.6471
p.P277S	ACH-000985	Colon/Colorectal Cancer	CCLE	PPGTPPPS	DEG_SCF_FBW7_1	0.0556
p.P277S	LS-411N	large_intestine	COSMIC	PPGTPPPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VAB6	Kinase suppressor of Ras 2	DEG_SCF_FBW7_1	287:294	PPGTPPPS	FBXW7	0.9991	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SCF_FBW7_1	213:220	PPGTPPPS	FBXW7	0.968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGTPPPS

Degron related mutations and impact score

Drug responses associated with KSR2 mutations

All proteins holding degron of PPGTPPPS