DegronMD

Uniprot ID: Q9BQQ3

Source protein: Golgi reassembly-stacking protein 1

Source gene: GORASP1

Class: DEG_SCF_FBW7_1

Location: 234:241

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 83.2375

COIL: 0.9529

CONS_SCORE: 0.2294

DSS_SCORE: 0.8964

HELIX: 0.0261

FCONS_SCORE: 0.9772

RIG_SCORE: 0.5132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A249T	DO8858	COAD	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	0.1111
p.D235E	DO228986	LICA	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	0.6758
p.A241D	DO229027	LICA	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	0.7793
p.L231P	DO43178	UCEC	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	0.25
p.T232I	DO41199	UCEC	ICGC	PGPTPEDS	DEG_SCF_FBW7_1	0.2778
p.E239K	SIDM01559	Melanoma	GDSC	PGPTPEDS	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SCF_FBW7_1	234:241	PGPTPEDS	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons