DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
AVSTS
Uniprot ID:
Q6PJG2
Source protein:
Mitotic deacetylase-associated SANT domain protein
Source gene:
MIDEAS
Class:
DEG_SPOP_SBC_1
Location:
55:59
E3 ligase:
SPOP
DEGRON score:
0.8176
ASA_SCORE:
84.72
COIL:
0.9466
CONS_SCORE:
0.4436
DSS_SCORE:
0.6966
HELIX:
0.0158
FCONS_SCORE:
1.0195
RIG_SCORE:
0.6137
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P67H
SIDM01169
Ovarian Carcinoma
GDSC
AVSTS
DEG_SPOP_SBC_1
0.1111
p.V56F
SIDM00220
Ovarian Carcinoma
GDSC
AVSTS
DEG_SPOP_SBC_1
0.5957
Drug responses associated with MIDEAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AVSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14776
Transcription elongation regulator 1
DEG_SPOP_SBC_1
269:273
AVSTS
SPOP
0.9767
More...
O95271
Poly [ADP-ribose] polymerase tankyrase-1
DEG_SPOP_SBC_1
107:111
AVSTS
SPOP
0.7984
More...
P35914
Hydroxymethylglutaryl-CoA lyase, mitochondrial
DEG_SPOP_SBC_1
20:24
AVSTS
SPOP
0.9441
More...
P43146
Netrin receptor DCC
DEG_SPOP_SBC_1
536:540
AVSTS
SPOP
0.6288
More...
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
DEG_SPOP_SBC_1
397:401
AVSTS
SPOP
0.9758
More...
Q9BQQ3
Golgi reassembly-stacking protein 1
DEG_SPOP_SBC_1
337:341
AVSTS
SPOP
0.9472
More...
Q9H2F9
Coiled-coil domain-containing protein 68
DEG_SPOP_SBC_1
313:317
AVSTS
SPOP
0.9865
More...
Q9HCE6
Rho guanine nucleotide exchange factor 10-like protein
DEG_SPOP_SBC_1
816:820
AVSTS
SPOP
0.6394
More...
Q9UBL3
Set1/Ash2 histone methyltransferase complex subunit ASH2
DEG_SPOP_SBC_1
276:280
AVSTS
SPOP
0.9612
More...
Q63HK3
Zinc finger protein with KRAB and SCAN domains 2
DEG_SPOP_SBC_1
271:275
AVSTS
SPOP
0.9672
More...
Q6PJG2
Mitotic deacetylase-associated SANT domain protein
DEG_SPOP_SBC_1
55:59
AVSTS
SPOP
0.8176
More...
Q92545
Transmembrane protein 131
DEG_SPOP_SBC_1
16:20
AVSTS
SPOP
0.7143
More...