DegronMD - Q9HCE6(ARHGEF10L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G897R	TCGA-AP-A0LM	UCEC	TCGA	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.2222
p.C809Y	TCGA-AP-A1DK	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1389
p.A160D	TCGA-DD-AACP	LIHC	TCGA	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.A160D	DO52210	LIHC	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.L821I	TCGA-EE-A184	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.3056
p.G145V	TCGA-EE-A2MR	SKCM	TCGA	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.25
p.P806S	TCGA-EE-A3AE	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0556
p.E179D	TCGA-VQ-A8P2	STAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation altering degron motif	0.5647
p.P190R	DO225098	BRCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1389
p.F159L	DO9698	COAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1944
p.P808H	DO230311	COCA	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1111
p.R141H	DO234329	ESAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1389
p.G152R	DO233223	GACA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation altering degron motif	0.7568
p.G814W	DO20831	KIRP	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.H142R	DO51009	LAML	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	DO229047	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	SIDM00569	Osteosarcoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	SIDM01494	Glioblastoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	SIDM01756	Chronic Myelogenous Leukemia	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	NY	bone	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.H142R	TE-8	oesophagus	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.S138I	DO228985	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation blocking phosphorylation signal	0.5
p.M163I	DO229019	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.0833
p.M825I	DO229029	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1944
p.C890F	DO229025	LICA	ICGC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation altering degron motif	0.7108
p.G819V	DO229037	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7532
p.A902T	DO52374	LUSC	ICGC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0833
p.A902T	DO42713	UCEC	ICGC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0833
p.S147F	DO222708	MELA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.3056
p.W822R	DO232832	NACA	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2778
p.A178T	DO32606	OV	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation altering degron motif	0.7139
p.G819D	DO229472	PRAD	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7198
p.P889Q	DO36310	PRAD	ICGC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation altering degron motif	0.7035
p.S158L	DO36284	PRAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.2222
p.K189N	DO47092	RECA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1667
p.S140F	DO47265	SKCM	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1111
p.L816I	DO47442	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation altering degron motif	0.7174
p.A900T	DO38743	STAD	ICGC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.1389
p.S147P	DO47867	STAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.3056
p.P829L	DO38195	STAD	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.0833
p.V172M	DO229211	THCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1667
p.V172M	DO41871	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1667
p.V810A	DO42177	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.Y171H	DO43434	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1389
p.V142M	DO42280	UCEC	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1667
p.I182T	DO41999	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation altering degron motif	0.7078
p.A164V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.0556
p.I894V	SIDM00705	Non-Cancerous	GDSC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.3056
p.S887P	SIDM00305	Ovarian Carcinoma	GDSC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation altering degron motif	0.5641
p.D140E	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1111
p.D140E	ACH-002311	Esophageal Cancer	CCLE	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1111
p.D140E	TE-12	oesophagus	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1111
p.R162W	SIDM00850	Gastric Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation rewiring degron network	0.1111
p.Q875L	ACH-000080	Leukemia	CCLE	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0556
p.V191I	ACH-000216	Esophageal Cancer	CCLE	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1111
p.E879K	ACH-000323	Brain Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.1667
p.E879K	ACH-000943	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.1667
p.L902M	ACH-000997	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0833
p.L902M	ACH-001061	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0833
p.L902M	HCT-15	large intestine	COSMIC	DPSATVHPT	DEG_SIAH_1	885:893	Mutation rewiring degron network	0.0833
p.A826T	RL95-2	endometrium	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.A826T	SNU-1040	large intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.A826T	8505C	thyroid	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.C150R	LS-411N	large intestine	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation altering degron motif	0.8301
p.S152C	REH	haematopoietic and lymphoid tissue	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	148:154	Mutation altering degron motif	0.7541
p.S189G	C-33-A	cervix	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.1667
p.R810H	LS-180	large intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1667
p.Y827F	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.1389
p.S182F	SW684	soft tissue	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation altering degron motif	0.7982
p.V192M	TOV-21G	ovary	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	178:183	Mutation rewiring degron network	0.0833
p.N824S	NCI-H28	pleura	COSMIC	AVSTS	DEG_SPOP_SBC_1	816:820	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF10L

UniProt ID: Q9HCE6

Entrez ID: 55160

Protein name: Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF10L in