DegronMD

Uniprot ID: Q9HCE6

Source protein: Rho guanine nucleotide exchange factor 10-like protein

Source gene: ARHGEF10L

Class: LIG_APCC_ABBAyCdc20_2

Location: 148:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9297

ASA_SCORE: 83.8857

COIL: 0.4477

CONS_SCORE: 0.4157

DSS_SCORE: 0.5814

HELIX: 0.4696

FCONS_SCORE: 1.1791

RIG_SCORE: 0.7564

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A160D	TCGA-DD-AACP	LIHC	TCGA	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.A160D	DO52210	LIHC	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.G145V	TCGA-EE-A2MR	SKCM	TCGA	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.25
p.F159L	DO9698	COAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R141H	DO234329	ESAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1389
p.G152R	DO233223	GACA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.7568
p.H142R	DO51009	LAML	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	DO229047	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	SIDM00569	Osteosarcoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	SIDM01494	Glioblastoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	SIDM01756	Chronic Myelogenous Leukemia	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	NY	bone	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.H142R	TE-8	oesophagus	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.S138I	DO228985	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.5
p.M163I	DO229019	LICA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.S147F	DO222708	MELA	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S158L	DO36284	PRAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.2222
p.S140F	DO47265	SKCM	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.S147P	DO47867	STAD	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.V142M	DO42280	UCEC	ICGC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.A164V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.0556
p.D140E	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.D140E	ACH-002311	Esophageal Cancer	CCLE	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.D140E	TE-12	oesophagus	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R162W	SIDM00850	Gastric Carcinoma	GDSC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.C150R	LS-411N	large_intestine	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.8301
p.S152C	REH	haematopoietic_and_lymphoid_tissue	COSMIC	RNLLYED	LIG_APCC_ABBAyCdc20_2	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RNLLYED

Degron related mutations and impact score

Drug responses associated with ARHGEF10L mutations

All proteins holding degron of RNLLYED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	LIG_APCC_ABBAyCdc20_2	148:154	RNLLYED	APC,CDC20,FZR1	0.9297	More...