DegronMD

Uniprot ID: Q9HCE6

Source protein: Rho guanine nucleotide exchange factor 10-like protein

Source gene: ARHGEF10L

Class: DEG_SIAH_1

Location: 885:893

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9338

ASA_SCORE: 70.9444

COIL: 0.836

CONS_SCORE: 0.334

DSS_SCORE: 0.3971

HELIX: 0.0884

FCONS_SCORE: 0.7674

RIG_SCORE: 0.7523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G897R	TCGA-AP-A0LM	UCEC	TCGA	DPSATVHPT	DEG_SIAH_1	0.2222
p.C890F	DO229025	LICA	ICGC	DPSATVHPT	DEG_SIAH_1	0.7108
p.A902T	DO52374	LUSC	ICGC	DPSATVHPT	DEG_SIAH_1	0.0833
p.A902T	DO42713	UCEC	ICGC	DPSATVHPT	DEG_SIAH_1	0.0833
p.P889Q	DO36310	PRAD	ICGC	DPSATVHPT	DEG_SIAH_1	0.7035
p.A900T	DO38743	STAD	ICGC	DPSATVHPT	DEG_SIAH_1	0.1389
p.I894V	SIDM00705	Non-Cancerous	GDSC	DPSATVHPT	DEG_SIAH_1	0.3056
p.S887P	SIDM00305	Ovarian Carcinoma	GDSC	DPSATVHPT	DEG_SIAH_1	0.5641
p.Q875L	ACH-000080	Leukemia	CCLE	DPSATVHPT	DEG_SIAH_1	0.0556
p.E879K	ACH-000323	Brain Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	0.1667
p.E879K	ACH-000943	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	0.1667
p.L902M	ACH-000997	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	0.0833
p.L902M	ACH-001061	Colon/Colorectal Cancer	CCLE	DPSATVHPT	DEG_SIAH_1	0.0833
p.L902M	HCT-15	large_intestine	COSMIC	DPSATVHPT	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SIAH_1	885:893	DPSATVHPT	SIAH1,SIAH2,SIAH3	0.9338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons