DegronMD

Uniprot ID: Q9HCE6

Source protein: Rho guanine nucleotide exchange factor 10-like protein

Source gene: ARHGEF10L

Class: DEG_SPOP_SBC_1

Location: 816:820

E3 ligase: SPOP

DEGRON score: 0.6394

ASA_SCORE: 51.9

COIL: 0.8274

CONS_SCORE: 0.3178

DSS_SCORE: 0.0485

HELIX: 0.077

FCONS_SCORE: 0.7992

RIG_SCORE: 0.7934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C809Y	TCGA-AP-A1DK	UCEC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1389
p.L821I	TCGA-EE-A184	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.3056
p.P806S	TCGA-EE-A3AE	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.0556
p.P808H	DO230311	COCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1111
p.G814W	DO20831	KIRP	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2778
p.M825I	DO229029	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.G819V	DO229037	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7532
p.W822R	DO232832	NACA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2778
p.G819D	DO229472	PRAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7198
p.L816I	DO47442	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7174
p.P829L	DO38195	STAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.V810A	DO42177	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.A826T	RL95-2	endometrium	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.A826T	SNU-1040	large_intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.A826T	8505C	thyroid	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.R810H	LS-180	large_intestine	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.Y827F	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1389
p.N824S	NCI-H28	pleura	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	269:273	AVSTS	SPOP	0.9767	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	107:111	AVSTS	SPOP	0.7984	More...
P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	DEG_SPOP_SBC_1	20:24	AVSTS	SPOP	0.9441	More...
P43146	Netrin receptor DCC	DEG_SPOP_SBC_1	536:540	AVSTS	SPOP	0.6288	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	397:401	AVSTS	SPOP	0.9758	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SPOP_SBC_1	337:341	AVSTS	SPOP	0.9472	More...
Q9H2F9	Coiled-coil domain-containing protein 68	DEG_SPOP_SBC_1	313:317	AVSTS	SPOP	0.9865	More...
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SPOP_SBC_1	816:820	AVSTS	SPOP	0.6394	More...
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	DEG_SPOP_SBC_1	276:280	AVSTS	SPOP	0.9612	More...
Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	DEG_SPOP_SBC_1	271:275	AVSTS	SPOP	0.9672	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SPOP_SBC_1	55:59	AVSTS	SPOP	0.8176	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	16:20	AVSTS	SPOP	0.7143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons