DegronMD

Uniprot ID: Q5VT52

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 2

Source gene: RPRD2

Class: DEG_SPOP_SBC_1

Location: 397:401

E3 ligase: SPOP

DEGRON score: 0.9758

ASA_SCORE: 82.68

COIL: 0.9456

CONS_SCORE: 0.335

DSS_SCORE: 0.6151

HELIX: 0.0148

FCONS_SCORE: 0.9304

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T404I	TCGA-BP-4963	KIRC	TCGA	AVSTS	DEG_SPOP_SBC_1	0.25
p.K391E	TCGA-KN-8422	KICH	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2778
p.L403V	DO224847	BRCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2778
p.L403V	DO227473	BRCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.2778
p.N408K	DO45299	LIRI	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1389
p.P404S	DO224563	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.25
p.A387V	DO42280	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0556
p.S410Y	DO43186	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.T400N	DO41235	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	269:273	AVSTS	SPOP	0.9767	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	107:111	AVSTS	SPOP	0.7984	More...
P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	DEG_SPOP_SBC_1	20:24	AVSTS	SPOP	0.9441	More...
P43146	Netrin receptor DCC	DEG_SPOP_SBC_1	536:540	AVSTS	SPOP	0.6288	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	397:401	AVSTS	SPOP	0.9758	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SPOP_SBC_1	337:341	AVSTS	SPOP	0.9472	More...
Q9H2F9	Coiled-coil domain-containing protein 68	DEG_SPOP_SBC_1	313:317	AVSTS	SPOP	0.9865	More...
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SPOP_SBC_1	816:820	AVSTS	SPOP	0.6394	More...
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	DEG_SPOP_SBC_1	276:280	AVSTS	SPOP	0.9612	More...
Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	DEG_SPOP_SBC_1	271:275	AVSTS	SPOP	0.9672	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SPOP_SBC_1	55:59	AVSTS	SPOP	0.8176	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	16:20	AVSTS	SPOP	0.7143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons