DegronMD

Uniprot ID: Q9UBL3

Source protein: Set1/Ash2 histone methyltransferase complex subunit ASH2

Source gene: ASH2L

Class: DEG_SPOP_SBC_1

Location: 276:280

E3 ligase: SPOP

DEGRON score: 0.9612

ASA_SCORE: 61.74

COIL: 0.6982

CONS_SCORE: 0.2897

DSS_SCORE: 0.5642

HELIX: 0.1224

FCONS_SCORE: 0.9118

RIG_SCORE: 0.6626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D269Y	TCGA-D3-A2JB	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.1389
p.P266S	TCGA-DK-A1AC	BLCA	TCGA	AVSTS	DEG_SPOP_SBC_1	0.0556
p.P266H	TCGA-EE-A2GK	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	0.0556
p.P266H	DO37738	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0556
p.N282Y	TCGA-F2-A44H	PAAD	TCGA	AVSTS	DEG_SPOP_SBC_1	0.2778
p.D267N	DO52615	BOCA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.P273H	DO233276	GACA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.25
p.R280I	DO25975	LUAD	ICGC	AVSTS	DEG_SPOP_SBC_1	0.8102
p.E285K	DO223721	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1944
p.D277N	DO220886	MELA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.6932
p.A270T	DO220886	MELA	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.P275S	DO50288	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	0.3056
p.R286W	DO43755	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	0.1667
p.G290E	ACH-000746	Gastric Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	0.0556
p.D289N	Sarc9371	bone	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.0833
p.Y268H	IGROV-1	ovary	COSMIC	AVSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	269:273	AVSTS	SPOP	0.9767	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	107:111	AVSTS	SPOP	0.7984	More...
P35914	Hydroxymethylglutaryl-CoA lyase, mitochondrial	DEG_SPOP_SBC_1	20:24	AVSTS	SPOP	0.9441	More...
P43146	Netrin receptor DCC	DEG_SPOP_SBC_1	536:540	AVSTS	SPOP	0.6288	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	397:401	AVSTS	SPOP	0.9758	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	DEG_SPOP_SBC_1	337:341	AVSTS	SPOP	0.9472	More...
Q9H2F9	Coiled-coil domain-containing protein 68	DEG_SPOP_SBC_1	313:317	AVSTS	SPOP	0.9865	More...
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_SPOP_SBC_1	816:820	AVSTS	SPOP	0.6394	More...
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2	DEG_SPOP_SBC_1	276:280	AVSTS	SPOP	0.9612	More...
Q63HK3	Zinc finger protein with KRAB and SCAN domains 2	DEG_SPOP_SBC_1	271:275	AVSTS	SPOP	0.9672	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	DEG_SPOP_SBC_1	55:59	AVSTS	SPOP	0.8176	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	16:20	AVSTS	SPOP	0.7143	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons