DegronMD - Q9UBL3(ASH2L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D269Y	TCGA-D3-A2JB	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.P266S	TCGA-DK-A1AC	BLCA	TCGA	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.P266H	TCGA-EE-A2GK	SKCM	TCGA	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.P266H	DO37738	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.N282Y	TCGA-F2-A44H	PAAD	TCGA	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.D267N	DO52615	BOCA	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P273H	DO233276	GACA	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.R280I	DO25975	LUAD	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.8102
p.E285K	DO223721	LUSC	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1944
p.D277N	DO220886	MELA	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.6932
p.A270T	DO220886	MELA	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.P275S	DO50288	SKCM	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.R286W	DO43755	UCEC	ICGC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.G290E	ACH-000746	Gastric Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.D289N	Sarc9371	bone	COSMIC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.Y268H	IGROV-1	ovary	COSMIC	AVSTS	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons