DegronMD

Uniprot ID: Q9HCE6

Source protein: Rho guanine nucleotide exchange factor 10-like protein

Source gene: ARHGEF10L

Class: DEG_Kelch_Keap1_1

Location: 178:183

E3 ligase: KEAP1

DEGRON score: 0.8063

ASA_SCORE: 93.5333

COIL: 0.874

CONS_SCORE: 0.4179

DSS_SCORE: 0.6244

HELIX: 0.1038

FCONS_SCORE: 1.0722

RIG_SCORE: 0.579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E179D	TCGA-VQ-A8P2	STAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.5647
p.P190R	DO225098	BRCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.A178T	DO32606	OV	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.7139
p.K189N	DO47092	RECA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1667
p.V172M	DO229211	THCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1667
p.V172M	DO41871	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1667
p.Y171H	DO43434	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.I182T	DO41999	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.7078
p.V191I	ACH-000216	Esophageal Cancer	CCLE	SEDSGE	DEG_Kelch_Keap1_1	0.1111
p.S189G	C-33-A	cervix	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	0.1667
p.S182F	SW684	soft_tissue	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	0.7982
p.V192M	TOV-21G	ovary	COSMIC	SEDSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_Kelch_Keap1_1	178:183	SEDSGE	KEAP1	0.8063	More...
Q2WGN9	GRB2-associated-binding protein 4	DEG_Kelch_Keap1_1	482:487	SEDSGE	KEAP1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons