DegronMD - Q2WGN9(GAB4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y489H	TCGA-44-8120	LUAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.2778
p.Y489H	DO45402	LUAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.2778
p.L490I	TCGA-97-8547	LUAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.L490I	DO49870	LUAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.Q475H	TCGA-B5-A0JY	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.Q475H	DO43041	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.R488K	TCGA-B5-A3FA	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.R488K	DO52402	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.P492S	TCGA-BF-AAOX	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1944
p.P492S	DO223907	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1944
p.D481N	TCGA-EE-A29M	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.D481N	TCGA-FR-A726	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.D481N	DO37404	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.D481N	DO48665	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.3056
p.A497V	TCGA-EY-A215	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.0556
p.A497V	DO42665	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.0556
p.P494L	TCGA-FW-A3R5	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.P494L	DO37406	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.P494S	TCGA-FW-A3R5	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.P494S	DO37406	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.L490R	TCGA-VQ-A922	STAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.L490R	DO50406	ESAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.L490R	DO233671	GACA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.L490R	DO51794	STAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.25
p.P494R	DO229264	THCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1389
p.T474M	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1111
p.T474M	SIDM00628	Breast Carcinoma	GDSC	SEDSGE	DEG_Kelch_Keap1_1	482:487	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAB4

UniProt ID: Q2WGN9

Entrez ID: 128954

Protein name: GRB2-associated-binding protein 4 (GRB2-associated binder 2-like) (GAB2-like) (GRB2-associated binder 4) (GRB2-associated-binding protein 2-like) (Growth factor receptor bound protein 2-associated protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAB4 in