DegronMD

Uniprot ID: Q2WGN9

Source protein: GRB2-associated-binding protein 4

Source gene: GAB4

Class: DEG_Kelch_Keap1_1

Location: 482:487

E3 ligase: KEAP1

DEGRON score: 0.9834

ASA_SCORE: 82.35

COIL: 0.8518

CONS_SCORE: 0.2773

DSS_SCORE: 0.6511

HELIX: 0.0965

FCONS_SCORE: 1.2305

RIG_SCORE: 0.6674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y489H	TCGA-44-8120	LUAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.2778
p.Y489H	DO45402	LUAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.2778
p.L490I	TCGA-97-8547	LUAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.L490I	DO49870	LUAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.Q475H	TCGA-B5-A0JY	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.Q475H	DO43041	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.R488K	TCGA-B5-A3FA	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.R488K	DO52402	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.P492S	TCGA-BF-AAOX	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.1944
p.P492S	DO223907	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1944
p.D481N	TCGA-EE-A29M	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.D481N	TCGA-FR-A726	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.D481N	DO37404	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.D481N	DO48665	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.3056
p.A497V	TCGA-EY-A215	UCEC	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.0556
p.A497V	DO42665	UCEC	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.0556
p.P494L	TCGA-FW-A3R5	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.P494L	DO37406	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.P494S	TCGA-FW-A3R5	SKCM	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.P494S	DO37406	SKCM	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.L490R	TCGA-VQ-A922	STAD	TCGA	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.L490R	DO50406	ESAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.L490R	DO233671	GACA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.L490R	DO51794	STAD	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.25
p.P494R	DO229264	THCA	ICGC	SEDSGE	DEG_Kelch_Keap1_1	0.1389
p.T474M	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	SEDSGE	DEG_Kelch_Keap1_1	0.1111
p.T474M	SIDM00628	Breast Carcinoma	GDSC	SEDSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE6	Rho guanine nucleotide exchange factor 10-like protein	DEG_Kelch_Keap1_1	178:183	SEDSGE	KEAP1	0.8063	More...
Q2WGN9	GRB2-associated-binding protein 4	DEG_Kelch_Keap1_1	482:487	SEDSGE	KEAP1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEDSGE

Degron related mutations and impact score

Drug responses associated with GAB4 mutations

All proteins holding degron of SEDSGE