DegronMD

Uniprot ID: P43146

Source protein: Netrin receptor DCC

Source gene: DCC

Class: DEG_SCF_FBW7_1

Location: 1361:1368

E3 ligase: FBXW7

DEGRON score: 0.9505

ASA_SCORE: 91.625

COIL: 0.9459

CONS_SCORE: 0.5776

DSS_SCORE: 0.5075

HELIX: 0.0259

FCONS_SCORE: 1.0411

RIG_SCORE: 0.7145

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1366I	TCGA-06-5416	GBM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.6063
p.L1366I	DO10880	GBM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.6063
p.P1362S	TCGA-A5-A0G2	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.5641
p.P1362S	DO41235	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.5641
p.L1366F	TCGA-AJ-A3EK	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.587
p.L1366F	DO41584	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.587
p.H1378R	TCGA-B5-A1MX	UCEC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.H1378R	DO41999	UCEC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.S1368P	TCGA-CS-6666	LGG	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.6752
p.S1368P	DO22309	LGG	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.6752
p.P1375T	TCGA-CV-A45W	HNSC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375T	DO52060	HNSC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375H	TCGA-CV-A45W	HNSC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375H	DO52060	HNSC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1351L	TCGA-EE-A17X	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.P1351L	DO37931	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.E1358K	TCGA-ER-A195	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.25
p.E1358K	TCGA-ER-A42L	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.25
p.E1358K	DO47712	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.25
p.E1358K	DO223910	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.25
p.P1375S	TCGA-IH-A3EA	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375S	TCGA-QB-AA9O	SKCM	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375S	DO229465	SKCA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375S	DO37667	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1375S	DO51267	SKCM	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1353A	TCGA-PD-A5DF	LIHC	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1111
p.P1353A	DO52307	LIHC	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1111
p.M1354I	TCGA-ZF-A9R9	BLCA	TCGA	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.M1354I	DO219066	BLCA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1389
p.P1353L	DO234350	ESAD	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.1111
p.H1378Y	DO50803	LIRI	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.P1351S	DO220903	MELA	ICGC	VPYTPLLS	DEG_SCF_FBW7_1	0.0556
p.V1376M	KMH-2	thyroid	COSMIC	VPYTPLLS	DEG_SCF_FBW7_1	0.2222
p.L1361I	H513	pleura	COSMIC	VPYTPLLS	DEG_SCF_FBW7_1	0.7174

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPYTPLLS

Degron related mutations and impact score

Drug responses associated with DCC mutations

All proteins holding degron of VPYTPLLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43146	Netrin receptor DCC	DEG_SCF_FBW7_1	1361:1368	VPYTPLLS	FBXW7	0.9505	More...