DegronMD

Uniprot ID: P43146

Source protein: Netrin receptor DCC

Source gene: DCC

Class: LIG_APCC_ABBA_1

Location: 1153:1158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8007

ASA_SCORE: 82.95

COIL: 0.6032

CONS_SCORE: 0.6136

DSS_SCORE: 0.6389

HELIX: 0.106

FCONS_SCORE: 1.0704

RIG_SCORE: 0.753

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1167E	TCGA-22-5489	LUSC	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.1944
p.K1167E	DO26480	LUSC	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1944
p.M1162I	TCGA-49-AARO	LUAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	TCGA-BF-A5EP	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	TCGA-EE-A182	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	DO218924	LUAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	DO220895	MELA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	DO37814	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.M1162I	DO223906	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.2222
p.P1151H	TCGA-55-8616	LUAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.2778
p.P1151H	DO23566	LUAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.2778
p.E1159D	TCGA-A5-A0G2	UCEC	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.E1159D	DO41235	UCEC	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.W1154C	TCGA-AX-A1CE	UCEC	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.5889
p.W1154C	DO42280	UCEC	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.5889
p.W1154L	TCGA-BF-A1Q0	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.5904
p.W1154L	DO47374	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.5904
p.E1161G	TCGA-BR-4361	STAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.25
p.E1161G	DO38887	STAD	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.25
p.E1161G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.25
p.E1161G	HCC-15	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.25
p.D1147N	TCGA-D3-A8GM	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.D1147N	TCGA-Z2-A8RT	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.D1147N	DO50288	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.D1147N	DO51301	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.D1147N	SIDM01577	Plasma Cell Myeloma	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.E1161K	TCGA-DX-A8BT	SARC	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.25
p.E1161K	DO220063	SARC	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.25
p.E1166K	TCGA-EE-A29E	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.1111
p.E1166K	DO37831	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1111
p.E1159K	TCGA-EE-A2M5	SKCM	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.E1159K	DO222423	MELA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.E1159K	DO37425	SKCM	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.L1148I	TCGA-GV-A3QK	BLCA	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.1944
p.L1148I	DO563	BLCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1944
p.D1147E	DO233246	GACA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.1667
p.P1150L	DO50970	LICA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.25
p.D1152N	DO229462	SKCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.H1156N	SIDM00652	Small Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.7423
p.H1156N	NCI-H1105	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.7423
p.G1143C	SIDM00223	Small Cell Lung Carcinoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.0556
p.G1143C	IST-SL1	lung	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.0556
p.S1144I	SIDM00410	Other Blood Cancers	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.0833
p.S1144I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.0833
p.A1151S	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.2778
p.D1154N	LOXIMVI	skin	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.6932
p.P1150T	SNU-81	large_intestine	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43146	Netrin receptor DCC	LIG_APCC_ABBA_1	1153:1158	LWIHHE	APC,CDC20,FZR1	0.8007	More...
Q92859	Neogenin	LIG_APCC_ABBA_1	1163:1168	LWIHHE	APC,CDC20,FZR1	0.9646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LWIHHE

Degron related mutations and impact score

Drug responses associated with DCC mutations

All proteins holding degron of LWIHHE