DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: LIG_APCC_ABBA_1

Location: 1163:1168

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9646

ASA_SCORE: 86.5167

COIL: 0.662

CONS_SCORE: 0.5797

DSS_SCORE: 0.4892

HELIX: 0.1998

FCONS_SCORE: 1.2758

RIG_SCORE: 0.7892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1162H	TCGA-BA-A6DA	HNSC	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.D1162H	TCGA-HC-8216	PRAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	0.3056
p.D1165N	DO1121	BRCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	0.6932
p.K1159R	SIDM00422	Hodgkin's Lymphoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	0.3333
p.K1159R	ACH-001203	Lymphoma	CCLE	LWIHHE	LIG_APCC_ABBA_1	0.3333
p.K1159R	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.3333
p.P1178S	CAL-33	upper_aerodigestive_tract	COSMIC	LWIHHE	LIG_APCC_ABBA_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons