DegronMD - Q92859(NEO1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1324Q	TCGA-06-1801	GBM	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1389
p.H1324Q	TCGA-06-1801	GBM	TCGA	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.1667
p.T1306I	TCGA-06-5416	GBM	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1389
p.L733I	TCGA-18-3416	LUSC	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6063
p.L733I	DO26423	LUSC	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6063
p.G1345D	TCGA-19-1387	GBM	TCGA	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.25
p.I1394L	TCGA-50-5930	LUAD	TCGA	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1111
p.V747L	TCGA-50-5933	LUAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1667
p.V747L	DO24800	LUAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1667
p.R737C	TCGA-A5-A1OF	UCEC	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.719
p.R737C	DO42568	UCEC	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.719
p.R748H	TCGA-A5-A1OF	UCEC	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1389
p.R748H	DO42568	UCEC	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1389
p.A1378T	TCGA-A6-6653	COAD	TCGA	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.3056
p.A1378T	TCGA-A6-6653	COAD	TCGA	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.25
p.R737H	TCGA-AA-3713	COAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.7133
p.R737H	DO8400	COAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.7133
p.D837N	TCGA-AR-A0TX	BRCA	TCGA	NAPYTPVP	CBL_PTK	842:849	Mutation rewiring degron network	0.1944
p.D837N	DO1663	BRCA	ICGC	NAPYTPVP	CBL_PTK	842:849	Mutation rewiring degron network	0.1944
p.S1316L	TCGA-AX-A0J0	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7667
p.S1316L	TCGA-BS-A0UF	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7667
p.S1316L	TCGA-CA-6717	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7667
p.S1316L	TCGA-EB-A3XD	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7667
p.S1316L	TCGA-EE-A2GC	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7667
p.R1304Q	TCGA-B5-A11N	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.0833
p.D1162H	TCGA-BA-A6DA	HNSC	TCGA	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1667
p.D1162H	TCGA-BA-A6DA	HNSC	TCGA	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation rewiring degron network	0.3056
p.D1162H	TCGA-HC-8216	PRAD	TCGA	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1667
p.D1162H	TCGA-HC-8216	PRAD	TCGA	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation rewiring degron network	0.3056
p.P1307T	TCGA-BQ-7049	KIRP	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1667
p.P1307T	TCGA-EB-A24D	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1667
p.V751I	TCGA-BR-8380	STAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.0556
p.V751I	DO47803	STAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.0556
p.L745F	TCGA-EB-A41A	SKCM	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.2222
p.L745F	DO37429	SKCM	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.2222
p.P1368L	TCGA-EE-A29D	SKCM	TCGA	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P1368L	SIDM00945	Colorectal Carcinoma	GDSC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P1368L	SIDM00057	Neuroblastoma	GDSC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P1368L	SIDM00552	Rhabdomyosarcoma	GDSC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P1368L	CL-34	large intestine	COSMIC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P1368L	KYM-1	soft tissue	COSMIC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.P857L	TCGA-EE-A2GI	SKCM	TCGA	NAPYTPVP	CBL_PTK	842:849	Mutation rewiring degron network	0.1111
p.P857L	DO37410	SKCM	ICGC	NAPYTPVP	CBL_PTK	842:849	Mutation rewiring degron network	0.1111
p.P1368S	TCGA-GN-A4U4	SKCM	TCGA	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.T1309I	TCGA-IZ-8196	KIRP	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.2222
p.T1306N	TCGA-KK-A7AV	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1389
p.S744C	TCGA-MN-A4N4	LUAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.25
p.S744C	DO26250	LUAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.25
p.I1367T	TCGA-VQ-A8P2	STAD	TCGA	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.1944
p.A1363V	TCGA-VQ-A8PT	STAD	TCGA	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1389
p.A1363V	TCGA-VQ-A8PT	STAD	TCGA	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.Q1184K	DO51894	BLCA	ICGC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1111
p.G1392R	DO49724	BLCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1667
p.D1165N	DO1121	BRCA	ICGC	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation altering degron motif	0.6932
p.D1332Y	DO222404	BTCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7325
p.P847L	DO222404	BTCA	ICGC	NAPYTPVP	CBL_PTK	842:849	Mutation altering degron motif	0.6471
p.A1367T	DO10373	COAD	ICGC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.1944
p.S1183A	DO8264	COAD	ICGC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1389
p.S1305L	DO8264	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.S1305L	DO222798	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.S1305L	DO37871	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.S1305L	DO37839	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.S1305L	DO41133	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.S1305L	DO41488	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.1111
p.P1369S	DO222737	COCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.0556
p.P1369S	DO222737	COCA	ICGC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.25
p.R1181H	DO52451	COCA	ICGC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1944
p.P1170S	DO234336	ESAD	ICGC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation altering degron motif	0.6752
p.R748C	DO233261	GACA	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1389
p.R748C	DO229257	THCA	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation rewiring degron network	0.1389
p.T1363S	DO233229	GACA	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1389
p.T1363S	DO233229	GACA	ICGC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.H1313Q	DO11986	GBM	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7582
p.G1334D	DO11573	GBM	ICGC	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7198
p.A843S	DO229015	LICA	ICGC	NAPYTPVP	CBL_PTK	842:849	Mutation altering degron motif	0.6477
p.V1353L	DO229025	LICA	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.6765
p.L1368F	DO229041	LICA	ICGC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.2222
p.I1383L	DO25189	LUAD	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7174
p.P847S	DO220886	MELA	ICGC	NAPYTPVP	CBL_PTK	842:849	Mutation altering degron motif	0.5641
p.P1357S	DO220899	MELA	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.3056
p.P1357S	DO51256	SKCM	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.3056
p.A1303V	DO228138	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.0556
p.S1390F	DO47331	SKCM	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.2222
p.S1390F	DO42608	UCEC	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.2222
p.P1357L	DO38123	SKCM	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.3056
p.P1357L	KYM-1	soft tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.3056
p.P1357L	CL-34	large intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.3056
p.A1352V	DO51776	STAD	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.6936
p.I1356T	DO51761	STAD	ICGC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.7078
p.R737S	DO229272	THCA	ICGC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6316
p.G1392W	DO39421	THCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1667
p.R1181C	DO41572	UCEC	ICGC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1944
p.R1181C	NB(TU)1-10	autonomic ganglia	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation rewiring degron network	0.1944
p.K1159R	SIDM00422	Hodgkin's Lymphoma	GDSC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation substituting flanking lysine	0.1944
p.K1159R	SIDM00422	Hodgkin's Lymphoma	GDSC	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation substituting flanking lysine	0.3333
p.K1159R	ACH-001203	Lymphoma	CCLE	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation substituting flanking lysine	0.1944
p.K1159R	ACH-001203	Lymphoma	CCLE	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation substituting flanking lysine	0.3333
p.K1159R	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation substituting flanking lysine	0.1944
p.K1159R	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation substituting flanking lysine	0.3333
p.V1364M	SIDM00367	Small Cell Lung Carcinoma	GDSC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1111
p.V1364M	SIDM00367	Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.1111
p.V1364M	SBC-3	lung	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1111
p.V1364M	SBC-3	lung	COSMIC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.1111
p.A1363T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1389
p.A1363T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.A1363T	ACH-000953	Leukemia	CCLE	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1389
p.A1363T	ACH-000953	Leukemia	CCLE	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.A1363T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.1389
p.A1363T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	1372:1375	Mutation rewiring degron network	0.0833
p.E1328K	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2778
p.E1328K	ACH-000886	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2778
p.E1328K	NCI-H2009	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2778
p.V738A	SIDM00217	Colorectal Carcinoma	GDSC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6936
p.V738A	ACH-000999	Colon/Colorectal Cancer	CCLE	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6936
p.V738A	SNU-1040	large intestine	COSMIC	ESDLDETRVPEV	DEG_COP1_1	730:741	Mutation altering degron motif	0.6936
p.T1350I	SIDM00783	Colorectal Carcinoma	GDSC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.5966
p.T1350I	ACH-000971	Colon/Colorectal Cancer	CCLE	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.5966
p.T1350I	HCT-116	large intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.5966
p.S1332N	ACH-001563	Skin Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7069
p.A1352T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.7139
p.P1315L	CL-34	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7582
p.P1315L	KYM-1	soft tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7582
p.V1311M	SBC-3	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.2778
p.E1317K	NCI-H2009	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation altering degron motif	0.7022
p.T1339I	HCT-116	large intestine	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation rewiring degron network	0.0833
p.T1339I	HCT-116	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.1944
p.V1353M	SBC-3	lung	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.7208
p.P1178S	CAL-33	upper aerodigestive tract	COSMIC	ERLELKPID	DEG_APCC_DBOX_1	1168:1176	Mutation blocking phosphorylation signal	0.7222
p.P1178S	CAL-33	upper aerodigestive tract	COSMIC	LWIHHE	LIG_APCC_ABBA_1	1163:1168	Mutation blocking phosphorylation signal	0.5
p.G1353E	COLO-679	skin	COSMIC	LPTAHVRPS	DEG_SIAH_1	1348:1356	Mutation altering degron motif	0.7199
p.G1395E	COLO-679	skin	COSMIC	LPSTPLLS	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.0833
p.A1310T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	1313:1317	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEO1

UniProt ID: Q92859

Entrez ID: 4756

Protein name: Neogenin (Immunoglobulin superfamily DCC subclass member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEO1 in