DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: DEG_SCF_FBW7_1

Location: 1379:1386

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 77.1

COIL: 0.8628

CONS_SCORE: 0.3491

DSS_SCORE: 0.5604

HELIX: 0.1091

FCONS_SCORE: 1.0568

RIG_SCORE: 0.7057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1394L	TCGA-50-5930	LUAD	TCGA	LPSTPLLS	DEG_SCF_FBW7_1	0.1111
p.A1378T	TCGA-A6-6653	COAD	TCGA	LPSTPLLS	DEG_SCF_FBW7_1	0.3056
p.G1392R	DO49724	BLCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.1667
p.P1369S	DO222737	COCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.0556
p.I1383L	DO25189	LUAD	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.7174
p.S1390F	DO47331	SKCM	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.2222
p.S1390F	DO42608	UCEC	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.2222
p.G1392W	DO39421	THCA	ICGC	LPSTPLLS	DEG_SCF_FBW7_1	0.1667
p.G1395E	COLO-679	skin	COSMIC	LPSTPLLS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92859	Neogenin	DEG_SCF_FBW7_1	1379:1386	LPSTPLLS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons